ArticleTrials2026
Supplemental Oxygen Strategies in children with BronchoPulmonary Dysplasia (the SOS BPD study): statistical analysis plan for a multicenter randomized controlled trial.
Article in Trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSupplemental oxygen remains the primary treatment for preterm infants with established bronchopulmonary dysplasia (BPD). Although randomized controlled trials have evaluated lower versus higher oxygen saturation targets in preterm infants before 36 weeks postmenstrual age, evidence beyond this age is lacking. The aim of the Supplemental Oxygen Strategies in children with BronchoPulmonary Dysplasia (SOS BPD) study is to evaluate the effect of a higher oxygen saturation lower limit of 95%, compared with a lower limit of 90%, on lung growth by proxy of weight standard deviation score (SDS), at 6 months corrected age in infants with established BPD. This document outlines the statistical analysis plan for the SOS-BPD study. METHODS/
designThe SOS BPD study is a multicenter, pragmatic, non-blinded, randomized trial in preterm infants with moderate or severe BPD. Eligible infants are randomized between 36 and 38 weeks postmenstrual age to a lower oxygen saturation limit of 95% or 90%, after parental informed consent. The assigned oxygen saturation lower limit is maintained until respiratory support can be discontinued. The primary outcome is weight SDS at 6 months corrected age. Secondary outcomes include anthropometrics measured at 6 and 12 months corrected age, rehospitalizations for respiratory reasons and respiratory complaints. This statistical analysis plan is written and submitted without knowledge of the data.
trial registrationOverview of Medical Research in the Netherlands (OMON), NL-OMON54694. Registered on 09-08-2018, URL: https://onderzoekmetmensen.nl/en/trial/54694 .
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.