Gut microenvironment-responsive copper selenide/disulfiram/eudragit

Yanwei Lv, Mengni Jiang, Qiwen Jiang, Xinyuan Zhang, Yijie Xie, Yunyi Yang, Shige Wang, Lianghao Hu, Jiulong Zhao

Abstract read

In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanwei Lv *Department of Gastroenterology, Changhai Hospital, Naval Medical University, No.168 Changhai Road, Shanghai, 200433, P. R. China.

Mengni Jiang *Department of Gastroenterology, Changhai Hospital, Naval Medical University, No.168 Changhai Road, Shanghai, 200433, P. R. China.

Qiwen Jiang *Department of Gastroenterology, Changhai Hospital, Naval Medical University, No.168 Changhai Road, Shanghai, 200433, P. R. China.

Xinyuan ZhangSchool of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai, 200093, P. R. China.

Yijie XieDepartment of Gastroenterology, Changhai Hospital, Naval Medical University, No.168 Changhai Road, Shanghai, 200433, P. R. China.

Yunyi YangDepartment of Gastroenterology, Changhai Hospital, Naval Medical University, No.168 Changhai Road, Shanghai, 200433, P. R. China.

Shige WangSchool of Materials and Chemistry, University of Shanghai for Science and Technology, No. 516 Jungong Road, Shanghai, 200093, P. R. China. sgwang@usst.edu.cn.

Lianghao HuDepartment of Gastroenterology, Changhai Hospital, Naval Medical University, No.168 Changhai Road, Shanghai, 200433, P. R. China. lianghao-hu@hotmail.com.

Jiulong ZhaoDepartment of Gastroenterology, Changhai Hospital, Naval Medical University, No.168 Changhai Road, Shanghai, 200433, P. R. China. jlzhao9@163.com.

Funding

National Natural Science Foundation of China 8227033745; 8257035413Shanghai Rising-Star Program 23QA1412000

6 · The paper itself

Abstract

Pyroptosis is involved in various inflammatory and fibrotic processes, but its specific role in the progression of chronic pancreatitis (CP) remains insufficiently explored. This study first investigated the dynamic expression changes of pyroptosis-related proteins during CP development and verified the regulatory effects of disulfiram (DSF) on key effector cells in CP, namely pancreatic stellate cells (PSCs) and macrophages. Building on these findings, a gut microenvironment-responsive nanoplatform, CuSe/DSF/EL nanoflowers, was designed and synthesized by integrating CuSe (as a carrier and selenium donor), DSF (as the core therapeutic agent), and Eudragit

Indexed as

CopperDisulfiramPancreatic Stellate CellsPancreatitis, ChronicPolymethacrylic AcidsPyroptosisAnimalsMaleMiceMice, Inbred C57BLSeleniumCopperDisulfirammethylmethacrylate-methacrylic acid copolymerPolymethacrylic AcidsSeleniumChronic pancreatitisCuSe NanoflowersDisulfiramPancreatic stellate cellPyroptosis

Identifiers

PMID42277854

DOI10.1186/s12951-026-04669-8

PMCPMC13488160

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.