Evidence map›Paper›PMID 42277796›Full record

ArticleJournal of nanobiotechnology2026

Spatially confined multi-enzyme cascade nanoreactor for portable and real-time pesticide detection.

Wei Zhang, Jia Shu, Chonghai Gong, Song Zhou, Hanting Wang, Kunyang Feng, Dongmei Liu, Rui Chen, Juan Li, Zhengwei Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wei Zhang *School of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Jia Shu *Ophthalmology Medical Center, Chongqing Key Laboratory for the Prevention and Treatment of Major Blinding Eye Diseases, Chongqing Branch (Municipality Division) of National Clinical Research Centre for Ocular Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.
Chonghai GongSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Song ZhouSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Hanting WangSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Kunyang FengSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China.
Dongmei LiuCollege of Pharmacy, Chongqing Medical University, Chongqing, 400016, China.
Rui ChenKey Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China.
Juan LiKey Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China. juanli0905@163.com.
Zhengwei ZhangCollege of Pharmacy, Chongqing Medical University, Chongqing, 400016, China. zzwcpu@cqmu.edu.cn.
Siqiao LiSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, 400016, China. lsqzzw@yeah.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multi-enzyme cascade reactions offer powerful amplification and accelerated biotransformation, yet their implementation in free-solution systems is limited by enzyme instability, diffusion losses, and low coupling efficiency. Here, we reported a spatially confined multi-enzyme cascade nanoreactor (AChE/CHO/HRP@MSN) constructed by co-immobilizing acetylcholinesterase (AChE), choline oxidase (CHO), and horseradish peroxidase (HRP) within amino-functionalized mesoporous silica nanoparticles (MSN-NH

Indexed as

Biosensing TechniquesNanoparticlesPesticidesAcetylcholinesteraseAlcohol OxidoreductasesColorimetryEnzymes, ImmobilizedHorseradish PeroxidaseOrganophosphorus CompoundsSilicon DioxideSmartphoneAcetylcholinesteraseAlcohol Oxidoreductasescholine oxidaseEnzymes, ImmobilizedHorseradish PeroxidaseOrganophosphorus CompoundsPesticidesSilicon DioxideDual-mode visual biosensingMulti-enzyme cascade nanoreactorOrganophosphorus pesticidesSpatial confinement

Identifiers

PMID42277796
PMCPMC13488018

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.