ArticleBMC infectious diseases2026
Carbapenem-resistant Enterobacterales infection at a South African paediatric hospital.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundCarbapenem-resistant Enterobacterales (CRE) cause significant morbidity and mortality. The global dissemination of CRE is a public health concern, and its impact on children is increasingly being recognised in low-and middle-income countries (LMIC). Studies describing paediatric CRE infections in LMIC are limited. Therefore, this study describes the incidence risk, clinical and microbiological characteristics, treatment, and outcome of children with CRE infections at Red Cross War Memorial Children's Hospital (RCWMCH) in Cape Town, South Africa.
methodsA retrospective description was completed on CRE infections diagnosed between January 2016 and December 2021. Clinical and laboratory data were extracted from hospital records and the National Health Laboratory Service database.
resultsThe overall incidence risk was 8.4/10,000 admissions. Of 85 infections with sufficient clinical and/or antibiotic information, the median age at CRE diagnosis was 3.9 months (interquartile range 0.8-44.4) and (68/85, 85%) were healthcare-associated. Sites of CRE infection included bloodstream (33/85, 39%), urinary tract (19/85, 22%) and respiratory tract (18/85, 21%). Klebsiella species (58/85, 68%) of which Klebsiella pneumoniae (57/58) predominated, and Serratia marcescens (19/85, 22%) were most isolated. Carbapenemase genes were detected in 63 of 72 isolates tested and included
conclusionThis study adds to the limited number of paediatric CRE studies from Africa. The predominant pathogen causing CRE infection was
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