Evidence map›Paper›PMID 42277625›Full record

ArticleAdvanced healthcare materials2026

Fructose-Based Single-Chain Polymer Nanoparticles for GLUT1-Mediated Delivery: Impact of Polymer Design on Uptake and In Vivo Performance.

Hoang Yen Vo, Linqing Tian, Qiaoyun Wang, Evelyn Szabo, Rebecca Y Lai, Fariba Dehghani, Martina H Stenzel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hoang Yen VoSchool of Chemistry, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0002-9764-5520
Linqing TianSchool of Chemistry, University of New South Wales, Sydney, Australia.
Qiaoyun WangSchool of Chemistry, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0002-9939-8711
Evelyn SzaboSchool of Chemistry, University of New South Wales, Sydney, Australia.
Rebecca Y LaiSchool of Chemistry, University of New South Wales, Sydney, Australia.
Fariba DehghaniSchool of Chemical and Biomolecular Engineering, University of Sydney, Darlington, Australia.ORCID https://orcid.org/0000-0002-7805-8101
Martina H StenzelSchool of Chemistry, University of New South Wales, Sydney, Australia.ORCID https://orcid.org/0000-0002-6433-4419

Funding

Australian Research Council FL200100124
6 · The paper itself

Abstract

We introduce the preparation and biological evaluation of head-tail, tadpole-like, single-chain nanoparticle (SCNP). These libraries are designed to study the influence of block arrangement on cellular uptake and biodistribution. In the first library, PEG-NPs consisted of a PEG-based crosslinked head with a fructose-containing glycopolymer tail (PEG-head), while the design was reversed in the second library (Fru-head). Cellular uptake studies revealed significantly higher uptake of NPs with Fru-head compared to NPs with PEG head, which is attributed to the surface accessibility of the fructose units to glucose transporters (GLUT). In contrast, the fructose moieties in PEG-NPs are more likely to be embedded within the core of the PEG head, thereby limiting receptor interaction. Additionally, uptake selectivity followed the order MDA-MB-231 > MCF-7 > RAW 264.7, correlating with GLUT expression levels. Mechanistic studies showed that uptake is strongly suppressed by GLUT1 inhibition but surprisingly unaffected by GLUT5 inhibition, a finding attributed to the pyranose structure of fructose. Fru-head tadpoles showed prolonged blood circulation and reduced clearance in vivo, with a mean residence time (MRD) of around 21 h, depending on the length of the PEG tail.

Indexed as

FructoseGlucose Transporter Type 1NanoparticlesPolymersAnimalsCell Line, TumorFemaleGlucose Transporter Type 5HumansMicePolyethylene GlycolsTissue DistributionFructoseGlucose Transporter Type 1Glucose Transporter Type 5Polyethylene GlycolsPolymersbreast cancercell uptakefructose‐based NPsGLUT transporterin vivoSingle‐chain nanoparticles

Identifiers

PMID42277625
PMCPMC13378471

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.