Evidence map›Paper›PMID 42277612›Full record

ArticlePest management science2026

DEET-cyclodextrin inclusion complexes for mosquito and tick repellency: Extended repellency time and no zebrafish embryotoxicity.

Gessyka Rayana Silva Pereira, Gleidson Cardoso, Maria Luiza Kuhn Camargo, Michele Resende Machado, Mayara Macedo Barrozo, Juscelino Rodrigues, Gisele Augusto Rodrigues de Oliveira, Caio Monteiro, Christian Luz, Ricardo Neves Marreto and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gessyka Rayana Silva PereiraLaboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás, Setor Leste Universitário, Goiânia, Brazil.ORCID https://orcid.org/0000-0002-7558-3461
Gleidson CardosoLaboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás, Setor Leste Universitário, Goiânia, Brazil.ORCID https://orcid.org/0000-0002-6370-0982
Maria Luiza Kuhn CamargoLaboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás, Setor Leste Universitário, Goiânia, Brazil.
Michele Resende MachadoEnvironmental Toxicology Research Laboratory, School of Pharmacy, Universidade Federal de Goiás, Goiânia, Brazil.
Mayara Macedo BarrozoBiology, Ecology and Tick Control Laboratory, Veterinary and Animal Science School, Universidade Federal de Goiás, Goiânia, Brazil.ORCID https://orcid.org/0000-0003-0340-6666
Juscelino RodriguesInvertebrate Pathology Laboratory, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Brazil.ORCID https://orcid.org/0000-0002-1277-8966
Gisele Augusto Rodrigues de OliveiraEnvironmental Toxicology Research Laboratory, School of Pharmacy, Universidade Federal de Goiás, Goiânia, Brazil.ORCID https://orcid.org/0000-0002-0758-2707
Caio MonteiroBiology, Ecology and Tick Control Laboratory, Veterinary and Animal Science School, Universidade Federal de Goiás, Goiânia, Brazil.ORCID https://orcid.org/0000-0001-5253-5451
Christian LuzInvertebrate Pathology Laboratory, Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, Brazil.ORCID https://orcid.org/0000-0002-5231-0735
Ricardo Neves MarretoLaboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás, Setor Leste Universitário, Goiânia, Brazil.ORCID https://orcid.org/0000-0003-3434-4656
Stephânia Fleury TaveiraLaboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy, Universidade Federal de Goiás, Setor Leste Universitário, Goiânia, Brazil.ORCID https://orcid.org/0000-0003-3844-6334

Funding

AshlandConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de GoiásIQUEGO
6 · The paper itself

Abstract

backgroundRepellent formulations are a cost-effective strategy for protection against disease vectors. N,N-diethyl-meta-toluamide (DEET) is widely used to repel mosquitoes and ticks, including Amblyomma sculptum, the vector of Rickettsia rickettsii (the agent of Brazilian spotted fever), and Aedes aegypti, responsible for dengue, zika, and chikungunya. This study aimed to develop cyclodextrin (CD)-DEET complexes for topical application. Phase-solubility studies identified the most suitable CD, and hydroxypropyl-β-cyclodextrin (HPβCD)-DEET was selected for further investigation. In vitro release and skin permeation were evaluated. Embryotoxicity was assessed in a zebrafish model, and repellent efficacy was investigated against both species.

resultsPhase-solubility studies revealed A

conclusionThese results highlight the potential of HPβCD-DEET complexes for safer and effective repellent formulations. © 2026 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

AmblyommaCyclodextrinsDEETInsect RepellentsZebrafishAedesAnimalsEmbryo, NonmammalianCyclodextrinsDEETInsect RepellentsHPβCD–DEET complexrepellent formulationslow releasetopical administrationvector

Identifiers

PMID42277612
PMCPMC13569254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.