Evidence map›Paper›PMID 42277589›Full record

ArticleJournal of cellular and molecular medicine2026

Redox Imbalance and NOS-Dependent Modulation of Superoxide in the Bladder Mucosa of Women With IC/BPS: A Preliminary Study.

Mariana G de Oliveira, Edson Antunes, Gabriela Reolon Passos, Luiz Gustavo Oliveira Brito, Carlos Arturo Levi D'Ancona, Fabíola Z Monica

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In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mariana G de OliveiraLaboratory of Pharmacology, São Francisco University (USF), Sao Paulo, Brazil.ORCID 0000-0003-2226-2530
Edson AntunesDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.ORCID 0000-0003-2201-8247
Gabriela Reolon PassosDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.
Luiz Gustavo Oliveira BritoDepartment of Obstetrics and Gynecology, University of Campinas Faculty of Medical Sciences, Campinas, Brazil.
Carlos Arturo Levi D'AnconaDepartment of Urology, Faculty of Medical Sciences, University of Campinas, São Paulo, Brazil.
Fabíola Z MonicaDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas, Campinas, Brazil.

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 17/15175-1Fundação de Amparo à Pesquisa do Estado de São Paulo 18/05956-9Fundação de Amparo à Pesquisa do Estado de São Paulo 18/09765-3Fundação de Amparo à Pesquisa do Estado de São Paulo 24/03517-9
6 · The paper itself

Abstract

Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic condition characterized by bladder/pelvic pain and urinary symptoms, with poorly defined mechanisms and no reliable biomarkers. Oxidative stress, particularly reactive oxygen species (ROS), has been implicated in its pathophysiology, but direct human evidence remains scarce. Here, we evaluated ROS- and nitric oxide (NO)-related pathways in bladder mucosa from women with IC/BPS (n = 5) and controls (n = 7). Gene expression of NO-cGMP components, NADPH oxidases (NOX1-5), and antioxidant enzymes was assessed by qPCR. Baseline NO and superoxide (

Indexed as

Cystitis, InterstitialMucous MembraneNitric Oxide SynthaseSuperoxidesUrinary BladderAdultCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5FemaleHumansMiddle AgedNADPH OxidasesNitric OxideNitric Oxide Synthase Type IIOxidation-ReductionOxidative StressCyclic GMPCyclic Nucleotide Phosphodiesterases, Type 5NADPH OxidasesNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IIReactive Oxygen SpeciesSuperoxidesbladder pain syndromeinterstitial cystitisnitric oxide synthasephosphodiesterasesuperoxide anion

Identifiers

PMID42277589
PMCPMC13259972

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.