ArticleAAPS PharmSciTech2026
Chloramphenicol Application Onto the Eyelid: Transfersomes for Enhanced Skin Delivery.
Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
4 authors.
Funding
Abstract
The aim of the study was to prepare chloramphenicol (CAM)-loaded transfersomes to enhance drug permeability following topical administration, considering the final goal of treating conjunctivitis by applying the formulation onto the eyelid. The CAM-loaded transfersomes obtained have an average particle size of approximately 120 nm, are monodispersed with polydispersity index < 0.1, and exhibit high encapsulation efficiency (84 ± 5.5%). The formulation showed vesicle deformability, good biocompatibility and enhanced skin permeation compared to a conventional ophthalmic formulation of the antibiotic. The optimized drug-loaded nanosystem was subsequently jellified and the fluid gel obtained presented rheological behaviour adequate for application onto the eyelid. The formulation showed physical and chemical stability after 3 months storage. Therefore, eyelid administration of CAM-loaded transfersomes could be considered as a potential strategy for the treatment of bacterial conjunctivitis.
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