Evidence map›Paper›PMID 42277468›Full record

ArticleCurrent microbiology2026

Genomic Insights into a New Burkholderia cenocepacia Sequence Type Linked to Cepacia Syndrome in Cystic Fibrosis.

Tatiane S Xavier, Felipe A Simão, Heloisa S Rosa, Jade C S Colomer, Renata W Cohen, Tânia W Folescu, Ana Paula D'A Carvalho-Assef, Robson S Leão, Elizabeth A Marques

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Article in Current microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tatiane S XavierLaboratório de Microbiologia da Fibrose Cística, Departamento de Microbiologia, Imunologia e Parasitologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0009-0005-5588-4952
Felipe A SimãoLaboratório de Microbiologia da Fibrose Cística, Departamento de Microbiologia, Imunologia e Parasitologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-8681-7657
Heloisa S RosaLaboratório de Microbiologia da Fibrose Cística, Departamento de Microbiologia, Imunologia e Parasitologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-5574-0821
Jade C S ColomerLaboratório de Microbiologia da Fibrose Cística, Departamento de Microbiologia, Imunologia e Parasitologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0009-0009-8107-5306
Renata W CohenInstituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Centro de Referência para Crianças e Adolescentes com Fibrose Cística - Ministério da Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0003-0596-4821
Tânia W FolescuInstituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Centro de Referência para Crianças e Adolescentes com Fibrose Cística - Ministério da Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-2958-5271
Ana Paula D'A Carvalho-AssefLaboratório de Bacteriologia Aplicada à Saúde Única e Resistência Antimicrobiana, Instituto Oswaldo Cruz, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0001-7044-4596
Robson S LeãoLaboratório de Microbiologia da Fibrose Cística, Departamento de Microbiologia, Imunologia e Parasitologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0003-0636-1520
Elizabeth A MarquesLaboratório de Microbiologia da Fibrose Cística, Departamento de Microbiologia, Imunologia e Parasitologia, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. marbe@uerj.br.ORCID http://orcid.org/0000-0003-3341-101X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Burkholderia cenocepacia is an important pathogen in cystic fibrosis (CF) patients, responsible for chronic lung infections and, in severe cases, cepacia syndrome (CS), characterized by necrotizing pneumonia, bacteremia, and high mortality. Epidemic lineages, such as B. cenocepacia J2315 (ET12) and ST32, are highly transmissible and frequently associated with CS. In this study, five B. cenocepacia isolates recovered from sputum and blood samples of a pediatric CF patient who developed CS were sequenced and analyzed in silico using multilocus sequence typing (MLST), phylogenomics, genomic similarity metrics, and comparative genomics to identify virulence determinants, resistance genes, and mobile genetic elements. A novel sequence type (ST2424), not associated with any known clonal complex, was identified. Phylogenomic analysis revealed high genetic relatedness among the isolates, consistent with a monoclonal infection undergoing within-host microevolution. Comparative analyses revealed distinct genetic profiles: aaiB (T6SS) was present in all isolates, whereas narG and manCcore were exclusive to bloodstream isolates. Acquired resistance determinants, including bla

Indexed as

Burkholderia cenocepaciaBurkholderia InfectionsCystic FibrosisGenome, BacterialGenomicsHumansMultilocus Sequence TypingPhylogenySputumVirulence FactorsVirulence Factors

Identifiers

PMID42277468
PMCPMC13260241

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.