Evidence map›Paper›PMID 42277465›Full record

ArticleJournal of gastroenterology2026

SEVs-carried ENPP1 regulates DCs' activation and inhibits the formation of tertiary lymphoid structures in gastric cancer.

Wenbo Liu, Bingyu Wang, Xinyu Yuan, Zhiran Yang, Yingying Wang, Zhiyuan Wang, Yong Li, Fang Li, Limian Er, Bibo Tan

Abstract read
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Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Wenbo Liu *The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Bingyu Wang *Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Xinyu YuanThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Zhiran YangThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Yingying WangThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Zhiyuan WangThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Yong LiThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Fang LiDepartment of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Limian ErDepartment of Endoscopy, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Bibo TanThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China. tanbibo@hebmu.edu.cn.ORCID http://orcid.org/0000-0001-6852-6947

Funding

Hebei Natural Science Foundation H2024206126Higher Education Graduate Innovation Funding Project of the Degree Office of the Education Department of Hebei Province CXZZBS2025107the 14th Five-Year Clinical Medicine Innovation Research Team Support Program of Hebei Medical University 2022LCTD-A13the S&T Program of Hebei 22377701D
6 · The paper itself

Abstract

backgroundEctonucleotide pyrophosphatase/phosphodiesterase 1(ENPP1) is a potential immune checkpoint, but the role and mechanism of small extracellular vesicles (sEVs)-carried ENPP1 in the formation of tertiary lymphoid structures (TLS) in gastric cancer (GC) are still unclear.

methodsGEO database, prognostic analysis, immune and single-cell analysis were used to explore the potential role of ENPP1 in GC. Electron microscopy, nanoparticle-tracking analysis identification and WB detection of marker proteins were used to verify the sEVs. Immunohistochemical staining, immunofluorescence staining, cell co-culture and flow cytometry were used to investigate the relationship among GC-derived sEVs-carried ENPP1 and dendritic cells (DCs) activation and TLS formation. Mice xenograft tumor model was used to explore the influence of sEVs-carried ENPP1 on vivo changes.

resultsENPP1 was highly expressed in GC tissues and cell lines and was associated with immune regulation. Immunohistochemistry showed that sEVs-carried ENPP1 expression was negatively correlated with the infiltration of DCs and CD8

conclusionsSEVs-carried ENPP1 regulates DCs' activation to inhibit TLS formation in GC. Our study illumes a new interaction mechanism between tumor cells and the immune microenvironment in GC.

Indexed as

Dendritic CellsExtracellular VesiclesPhosphoric Diester HydrolasesPyrophosphatasesStomach NeoplasmsTertiary Lymphoid StructuresAnimalsCD8-Positive T-LymphocytesCell Line, TumorCoculture TechniquesFemaleHumansMiceectonucleotide pyrophosphatase phosphodiesterase 1Phosphoric Diester HydrolasesPyrophosphatasesDendritic cellsEctonucleotide pyrophosphatase/phosphodiesterase 1Gastric cancerSmall extracellular vesiclesTertiary lymphoid structures

Identifiers

PMID42277465

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.