ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Treatment-related pain in refractory cancer pain: prevalence, mechanisms, and clinical implications in a tertiary referral cohort.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe long-term effects of cancer treatment are increasingly driving persistent pain in cancer survivors; however, the contribution and clinical profile of cancer treatment-related pain (CTRP) in refractory pain populations remain poorly defined.
methodsWe conducted a retrospective cohort study of consecutive patients (N = 622) referred to a tertiary multidisciplinary cancer pain clinic for initial evaluation of refractory pain (January 2021-June 2025). Pain etiology was classified using ICD-11 criteria as treatment-related pain (TRP; MG30.11), tumor-related pain (MG30.10), or non-cancer-related pain. The multivariate logistic regression analysis identified factors associated with TRP attribution.
resultsTRP was identified in 42.1% of patients (n = 262). Patients with TRP were younger than those with tumor-related pain (mean 58.1 ± 14.8 vs 64.2 ± 12.8 years, p < 0.001). Peripheral neuropathy was strongly associated with TRP attribution (adjusted odds ratio 9.18; 95% CI 2.56-32.83). Neuropathic (46.2%) and mixed (35.9%) mechanisms predominated in TRP, whereas nociceptive mechanisms were more common in tumor-related pain.
conclusionsTreatment-related pain constitutes a major component of refractory cancer pain and demonstrates a distinct clinical and mechanistic profiles. Its predominance among younger survivors supports its characterization as a survivorship-associated morbidity rather than an end-of-life phenomenon. These findings support the earlier recognition and integration of mechanism-informed, multidisciplinary supportive care strategies to improve outcomes in patients with persistent treatment-related pain.
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