Evidence map›Paper›PMID 42277427›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2026

Lentiviral GLP-1 gene therapy elicits developmental stage-dependent β-cell regeneration in diabetic rats.

Ezgi Erbasan, Melike Aliciaslan, Fulya Erendor, Sumeyye Sensoy, Busra Cetin, Mustafa Aydemir, Salih Sanlioglu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ezgi ErbasanDepartment of Gene and Cell Therapy, Faculty of Medicine, Akdeniz University, Antalya, 07058, Turkey.
Melike AliciaslanDepartment of Gene and Cell Therapy, Faculty of Medicine, Akdeniz University, Antalya, 07058, Turkey.
Fulya ErendorDepartment of Gene and Cell Therapy, Faculty of Medicine, Akdeniz University, Antalya, 07058, Turkey.
Sumeyye SensoyDepartment of Gene and Cell Therapy, Faculty of Medicine, Akdeniz University, Antalya, 07058, Turkey.
Busra CetinDepartment of Gene and Cell Therapy, Faculty of Medicine, Akdeniz University, Antalya, 07058, Turkey.
Mustafa AydemirDivision of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Akdeniz University, Antalya, 07058, Turkey.
Salih SanliogluDepartment of Gene and Cell Therapy, Faculty of Medicine, Akdeniz University, Antalya, 07058, Turkey. sanlioglu@akdeniz.edu.tr.ORCID http://orcid.org/0000-0001-8379-5678

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic β-cell differentiation and regenerative capacity differ markedly between developmental stages, with the neonatal pancreas exhibiting high plasticity that enables ongoing progenitor- and ductal-derived β-cell formation, whereas the adult pancreas demonstrates limited neogenic potential. Glucagon-like peptide-1 (GLP-1) promotes β-cell survival, proliferation, and differentiation; however, its developmental stage-specific effects on β-cell regeneration are not fully understood. To investigate this, we generated a third-generation HIV-based lentiviral vector encoding native GLP-1 (LentiGLP-1) under the control of cytomegalovirus (CMV) promoter using the Multisite Gateway

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Genetic TherapyGlucagon-Like Peptide 1Insulin-Secreting CellsLentivirusRegenerationAnimalsCell DifferentiationCell ProliferationGene Therapy AgentsGenetic VectorsMaleRatsGlucagon-Like Peptide 1Beta cell differentiationGene deliveryGlucagon-like peptide 1LentivirusType 2 diabetes mellitus

Identifiers

PMID42277427
PMCPMC13260127

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.