Evidence map›Paper›PMID 42277407›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2026

Association between blood pressure and risk of ischemic stroke among individuals with dementia: A nationwide cohort study.

Kye-Yeung Park, Ga Eun Nam, Kyungdo Han, Jin Hyung Jung, Jung Eun Yoo, Chung-Woo Lee, Sung Hoon Kang, Chi Kyung Kim, Dong Wook Shin

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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Kye-Yeung ParkDepartment of Family Medicine, Hanyang University College of Medicine, Seoul, South Korea.
Ga Eun NamDepartment of Family Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea. namgaaa@hanmail.net.
Kyungdo HanDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, South Korea.
Jin Hyung JungHealth Insurance Review and Assessment Service, Wonju, South Korea.
Jung Eun YooDepartment of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea.
Chung-Woo LeeDepartment of Family Medicine, Veterans Health Service Medical Center, Seoul, South Korea.
Sung Hoon KangDepartment of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea.
Chi Kyung KimDepartment of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, South Korea.
Dong Wook ShinDepartment of Family Medicine/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. dwshin.md@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prior research has established a positive correlation between blood pressure (BP) and ischemic stroke in the general population; however, this association has not been investigated in dementia patients. A population-based cohort of 73,130 individuals with newly diagnosed dementia who underwent a Korean national health checkup after diagnosis was followed up until the end of 2019. Individuals were classified according to their systolic (SBP) and diastolic BP (DBP) during health checkups. Multivariable Cox proportional hazards regression was performed, calculating the hazard ratios (HRs) and 95% confidence intervals (CIs) for incident ischemic stroke. During a mean follow-up of 3.6 years, 4446 (6.1%) patients developed ischemic stroke. In all-cause dementia patients, the risk of ischemic stroke increased after SBP/DBP exceeded 130/90 mmHg compared with SBP 120-129 mmHg and DBP 70-79 mmHg (reference) (both P for trend <0.001). Similar trends were observed in patients with Alzheimer's disease and vascular dementia. In particular, SBP/DBP ≥ 140/90 mmHg and SBP 100-109 mmHg were associated with incrementally higher risks of ischemic stroke and a decreased risk of Alzheimer's disease, respectively (both P for trend <0.001). The positive linear association of SBP and DBP with ischemic stroke in all-cause dementia remained after stratification by sex and antihypertensive medication use, and the association between SBP and ischemic stroke was greater among younger individuals (40-79 years old). In conclusion, both SBP and DBP showed positive linear relationships with the risk of incident ischemic stroke in dementia patients. Achievement of the target BP may be important for stroke prevention in individuals with dementia.

Indexed as

Blood PressureDementiaHypertensionIschemic StrokeAgedCohort StudiesFemaleHumansIncidenceMaleMiddle AgedRepublic of KoreaRisk FactorsAlzheimer’s diseaseBlood pressureCohort studyDementiaIschemic stroke

Identifiers

PMID42277407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.