Evidence map›Paper›PMID 42277363›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2026

Nucleus accumbens medial shell D1 and D2 medium spiny neurons signal the valence of conditioned stimuli in a sex-dependent manner.

Gabrielle Siemonsmeier, Eshaan S Iyer, Heike Schuler, Ariel M Weinbaum, Kristine Huang, Joëlle Lopez, Rosemary C Bagot

Abstract read
PubMed Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gabrielle SiemonsmeierIntegrated Program in Neuroscience, McGill University, Montréal, QC, Canada.ORCID http://orcid.org/0009-0000-9194-7862
Eshaan S IyerIntegrated Program in Neuroscience, McGill University, Montréal, QC, Canada.ORCID http://orcid.org/0000-0002-5408-5500
Heike SchulerIntegrated Program in Neuroscience, McGill University, Montréal, QC, Canada.ORCID http://orcid.org/0000-0002-8462-5491
Ariel M WeinbaumDepartment of Psychology, McGill University, Montréal, QC, Canada.
Kristine HuangDepartment of Psychology, McGill University, Montréal, QC, Canada.
Joëlle LopezDepartment of Psychology, McGill University, Montréal, QC, Canada.ORCID http://orcid.org/0000-0003-0221-6588
Rosemary C BagotDepartment of Psychology, McGill University, Montréal, QC, Canada. rosemary.bagot@mcgill.ca.ORCID http://orcid.org/0009-0005-5512-5294

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assigning valence to stimuli supports survival by promoting approach of stimuli associated with beneficial outcomes and avoidance of those associated with noxious outcomes, a process dysregulated in many psychiatric disorders. The nucleus accumbens (NAc) uses valence information to guide appropriate behavioral responses. NAc medium spiny neurons (MSNs) expressing D1 and D2 dopamine receptors have long been thought to play opponent roles in valence processing, although this has been challenged by recent work. To test this, we used fiber photometry Ca

Identifiers

PMID42277363

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.