Evidence map›Paper›PMID 42277334›Full record

ArticleScientific reports2026

IL-33 accelerates orthodontic tooth movement by promoting M1 differentiation of macrophages and osteoclast formation.

Zhengquan He, Huan Tian, Xingyu Liu, Yige Duan, Mengshan Chen, Zhenyan Luo

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhengquan HeChangsha Stomatological Hospital, No.389 Youyi Road, Tianxin District, Changsha, 410004, Hunan, China.
Huan TianChangsha Stomatological Hospital, No.389 Youyi Road, Tianxin District, Changsha, 410004, Hunan, China.
Xingyu LiuChangsha Stomatological Hospital, No.389 Youyi Road, Tianxin District, Changsha, 410004, Hunan, China.
Yige DuanChangsha Stomatological Hospital, No.389 Youyi Road, Tianxin District, Changsha, 410004, Hunan, China.
Mengshan ChenChangsha Stomatological Hospital, No.389 Youyi Road, Tianxin District, Changsha, 410004, Hunan, China.
Zhenyan LuoChangsha Stomatological Hospital, No.389 Youyi Road, Tianxin District, Changsha, 410004, Hunan, China. luozhenyan612@163.com.

Funding

Research Program of Hunan Provincial Health Commission 202208032486Research Project of Changsha Health Commission KJ-B2023086
6 · The paper itself

Abstract

Developing methods to promote tooth movement can help reduce the duration of orthodontic treatment for patients. A mouse model of orthodontic tooth movement (OTM) was established to analyze the key role of the IL-33/ST2 signaling pathway in this process. Human periodontal ligament fibroblasts (hPDLFs) and human CD14

Indexed as

Cell DifferentiationInterleukin-33MacrophagesOsteoclastsTooth Movement TechniquesAnimalsCells, CulturedFibroblastsHumansInterleukin-1 Receptor-Like 1 ProteinMaleMiceMonocytesPeriodontal LigamentSignal TransductionIl1rl1 protein, mouseIL33 protein, humanIl33 protein, mouseInterleukin-1 Receptor-Like 1 ProteinInterleukin-33IL-33MacrophagesOrthodontic tooth movementOsteoclastsPeriodontal ligament fibroblasts

Identifiers

PMID42277334
PMCPMC13507269

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.