Evidence map›Paper›PMID 42277287›Full record

ArticleBritish journal of cancer2026

Associations of alcohol use with expression of stromal markers in benign breast biopsy samples.

Anjoli Armstrong, Yujing J Heng, Brian R Sardella, Maisey Ratcliffe, Bernard Rosner, Rulla M Tamimi, Lusine Yaghjyan

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PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anjoli ArmstrongUniversity of Florida, College of Public Health and Health Professions and College of Medicine, Department of Epidemiology, Gainesville, FL, USA.
Yujing J HengDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8930-817X
Brian R SardellaDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Maisey RatcliffeUniversity of Florida, College of Public Health and Health Professions and College of Medicine, Department of Epidemiology, Gainesville, FL, USA.
Bernard RosnerChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-6907-0056
Rulla M TamimiDepartment of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2306-8668
Lusine YaghjyanUniversity of Florida, College of Public Health and Health Professions and College of Medicine, Department of Epidemiology, Gainesville, FL, USA. lyaghjyan@ufl.edu.ORCID http://orcid.org/0000-0002-1626-5340

Funding

Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8M
Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Long Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
Stromal contributions to breast carcinogenesisR01CA277817 · NCI · UNIVERSITY OF FLORIDA · PI Rulla M Tamimi, Lusine Yaghjyan · 2023 to 2026
$2.8M
Whole Genome Association Study of Mammographic DensityR01CA131332 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAMIMI, RULLA M · 2009 to 2012
$1.9M
Mammographic density and texture features in relation to breast cancer riskR01CA175080 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAMIMI, RULLA M · 2013 to 2016
$1.7M
The role of breast stem cells in breast cancer etiology and risk predictionR01CA240341 · NCI · UNIVERSITY OF FLORIDA · PI YAGHJYAN, LUSINE · 2020 to 2023
$1.4M
NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA131332NCI NIH HHS R01 CA175080NCI NIH HHS R01 CA240341NCI NIH HHS R01 CA277817NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA176726NCI NIH HHS UM1 CA186107U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA131332, CA175080, P01 CA087969, CA277817, CA240341, CA186107, CA176726U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA277817, CA240341
6 · The paper itself

Abstract

backgroundWe explored the associations of alcohol consumption with expression of α-Smooth Muscle Actin (α-SMA), Tenascin-C (TNC), Fibroblast Activation Protein (FAP), Matrix Metalloproteinase-14 (MMP14), and Calcyclin (s100a6) stromal markers in benign breast biopsy samples.

methodsThe study included 683 cancer-free women from the Nurses' Health Study II who had biopsy-confirmed benign breast disease (BBD). Alcohol consumption was assessed with semi-quantitative Food Frequency Questionnaires. The data on breast cancer (BCa) risk factors were obtained from biennial questionnaires. Immunofluorescence for stromal markers was performed on tissue microarrays. For each core, the % positivity was quantified by inForm v2.6.0. Generalised linear regression was used to examine associations between alcohol consumption (recent [at biopsy date] and cumulative average from all available questionnaires before the biopsy date) and log-transformed expression of each marker, adjusting for BCa risk factors and BBD subtype.

resultsIn multivariate analysis, we observed a suggestive positive association of cumulative average alcohol with TNC (β per 11 g/day = 0.59, 95% CI -0.03,1.22, p = 0.06). Alcohol consumption was not associated with α-SMA, FAP, s100a6, and MMP14.

conclusionAlcohol consumption may be associated with an increased normal stromal fibroblast activation as measured by TNC expression in histologically normal breast tissue. Future studies are warranted to confirm our findings.

Indexed as

Alcohol DrinkingBiomarkers, TumorBreastBreast DiseasesActinsAdultBiomarkersBiopsyBreast NeoplasmsCell Cycle ProteinsEndopeptidasesFemaleFibroblast Activation Protein AlphaGelatinasesHumansMembrane ProteinsActinsBiomarkersBiomarkers, TumorCell Cycle ProteinsEndopeptidasesFibroblast Activation Protein AlphaGelatinasesMembrane ProteinsS100A6 protein, humanS100 Calcium Binding Protein A6Tenascin

Identifiers

PMID42277287
PMCPMC13478342

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.