Evidence map›Paper›PMID 42277066›Full record

ArticleNature communications2026

Nationwide spread of multidrug resistant Klebsiella pneumoniae across US communities.

Jianping Jiang, Austin J Terlecky, Kevin J Rome, Elena Shashkina, Claudia Manca, Meghan W Starolis, Julia Larsen, Akinyosoye Olufunmi, Ariel A Aptekmann, Tara Lozy and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jianping Jiang *Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Austin J Terlecky *Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.ORCID http://orcid.org/0009-0005-8209-8922
Kevin J RomeCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.ORCID http://orcid.org/0000-0002-2262-4813
Elena ShashkinaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Claudia MancaCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Meghan W StarolisQuest Diagnostics, Secaucus, NJ, USA.
Julia LarsenQuest Diagnostics, Secaucus, NJ, USA.
Akinyosoye OlufunmiQuest Diagnostics, Secaucus, NJ, USA.
Ariel A AptekmannCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Tara LozyCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Kelly K YenCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Mia J BucichCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.
Robert S JonesQuest Diagnostics, Secaucus, NJ, USA.
Barun MathemaDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Johann D D PitoutDepartment of Pathology and Laboratory Medicine, Cummings School of Medicine, University of Calgary, Calgary, AB, Canada.
Liang ChenSchool of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA.ORCID http://orcid.org/0000-0001-5845-2235
Barry N KreiswirthCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA. barry.kreiswirth@hmh-cdi.org.ORCID http://orcid.org/0000-0002-0243-131X

Funding

Discovering accumulation guidelines and applying them to develop new antibiotics for Gram-negative pathogensR01AI191595 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Paul Hergenrother · 2025 to 2026
$2.3M
Dissecting the host-plasmid interplay to unravel the spread of ESBL-producing K. pneumoniaeU01AI187297 · NIAID · HACKENSACK UNIVERSITY MEDICAL CENTER · PI BARRY Neal KREISWIRTH · 2025 to 2026
$1.7M
Innovative Antibiotic Combinations for Hypervirulent Klebsiella pneumoniaeR21AI190454 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BULMAN, ZACKERY P., CHEN, LIANG · 2025 to 2025
$457k
NIAID NIH HHS R01 AI191595NIAID NIH HHS R21 AI190454NIAID NIH HHS U01 AI187297U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01AI191595U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U01AI187297
6 · The paper itself

Abstract

Traditionally viewed as a hospital pathogen, multidrug-resistant (MDR) Klebsiella pneumoniae is emerging in community settings, yet its population structure and spread are currently undefined. A nationwide genomic survey of 2006 ceftriaxone-nonsusceptible outpatient isolates from 42 US states reveals that the spread of resistance is primarily driven by the bla

Indexed as

Drug Resistance, Multiple, BacterialKlebsiella InfectionsKlebsiella pneumoniaeAgedAnti-Bacterial Agentsbeta-LactamasesCommunity-Acquired InfectionsFemaleHumansMicrobial Sensitivity TestsPlasmidsUnited StatesUrinary Tract InfectionsAnti-Bacterial Agentsbeta-lactamase CTX-M-15beta-Lactamases

Identifiers

PMID42277066
PMCPMC13407891

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.