Developmental variation in basal ganglia tissue iron, neurocognitive functioning, and impulsivity is associated with substance use trajectories in youth.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Ashley C ParrDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, US. parrac@upmc.edu.ORCID 0000-0002-5239-2996
Amar OjhaCenter for the Neural Basis of Cognition (CNBC), Carnegie Mellon University, Pittsburgh, PA, 15213, US.ORCID 0000-0002-1038-0225
Daniel J PetrieDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, US.
Finnegan J CalabroDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, US.
Brenden Tervo-ClemmensDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, 55455, US.ORCID 0000-0002-9557-1126
Will ForanDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, US.ORCID 0000-0001-7491-9798
Douglas FitzgeraldDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, US.
Susan F TapertDepartment of Psychiatry, University of California, San Diego, La Jolla, CA, 92093, US.ORCID 0000-0001-7259-6112
Kate NoonerDepartment of Psychology, University of North Carolina Wilmington, Wilmington, NC, 28403, US.ORCID 0000-0003-3756-649X
Wesley ThompsonOxley College of Health and Natural Sciences, University of Tulsa, Tulsa, OK, 74136, US.
David B GoldstonDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, 27705, US.
Duncan ClarkDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, US.
Beatriz LunaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, 15213, US.
Funding
NCANDA Research Project Site: DukeU01AA021681 · NIAAA · DUKE UNIVERSITY · PI DAVID B. GOLDSTON · 2012 to 2026
$9.8M
INTERDISCIPLINARY ALCOHOL RESEARCH TRAINING PROGRAMT32AA007453 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKE S.G. MOLINA · 1985 to 2026
$3.7M
Leveraging complementary big data methods and patient intervention designs to optimize neural markers of adolescent cannabis useK23DA057486 · NIDA · UNIVERSITY OF MINNESOTA · PI Brenden Craig Tervo-Clemmens · 2023 to 2026
$782k
NIAAA NIH HHS T32 AA007453NIAAA NIH HHS U01 AA021681U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) 5RO1MH080243-07U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) AA021681, AA021690, AA021691, AA021692, AA021695, AA021696, AA021697U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) K23DA057486
6 · The paper itself
Abstract
Neurodevelopmental models implicate dopaminergic and neurocognitive maturation in adolescent risk-taking, yet their joint contribution to substance use trajectories in humans remains unclear. We examined basal ganglia tissue iron, a marker of dopamine-related neurobiology, alongside impulsivity and inhibitory control in relation to longitudinal substance use patterns in the NCANDA-A cohort (N = 802; ages 12-30; 6,078 visits). Growth Mixture Models identified four trajectories: no/low use (30% of participants), youth peak (26%), adolescent increasing (17%), and adult increasing (26%). Substance use, inhibitory control, and tissue iron increased with age, while impulsivity declined. Greater substance use was associated with heightened impulsivity, low inhibitory control, and low tissue iron, prominently in early adolescence among youth peak patterns. Trajectories were further distinguished by divergent maturation of impulsivity and tissue iron. Results suggest that developmental variation in tissue iron and neurocognition contribute to youth substance use, highlighting adolescence as a sensitive window for risk stratification and prevention.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Developmental variation in basal ganglia tissue iron, neurocognitive functioning, and impulsivity is associated with substance use trajectories in youth. · full record | OpenQuestion