ArticleTranslational psychiatry2026
Divergent transcriptomic pathways underlie sex-biased cognitive rescue by developmental GSK3B inhibition in a mouse model of 22q11.2 deletion syndrome.
Johannes Passecker, Chia-Yuan Chang, Aleksandra Dagunts, Chloe M Aloimonos, Lukas Leitner, Arsenii Petryk, Florence F Wagner, Maxym V Myroshnychenko, David A Kupferschmidt, Joseph A Gogos and 1 more
Abstract read
In one paragraphArticle in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Johannes PasseckerIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892, USA. johannes.passecker@i-med.ac.at.
Aleksandra DaguntsIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892, USA.
Chloe M AloimonosIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892, USA.
Lukas LeitnerInstitute of Systems Neuroscience, Medical University of Innsbruck, Innsbruck, Austria.
Arsenii PetrykInstitute of Systems Neuroscience, Medical University of Innsbruck, Innsbruck, Austria.
Florence F WagnerThe Broad Institute of MIT and Harvard Center for the Development of Therapeutics, Cambridge, MA, 02142, USA.
Maxym V MyroshnychenkoIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892, USA.
David A KupferschmidtIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892, USA.
Funding
Mechanisms underlying the functional connectivity deficit in the 22q11 microdeletR01MH096274 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GOGOS, JOSEPH A · 2012 to 2021
$3.6MAustrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) P35747Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) 28622NIMH NIH HHS R01 MH096274U.S. Department of Health & Human Services | National Institutes of Health (NIH) 5R01MH096274-08U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS003168
6 · The paper itselfAbstract
Neuropsychiatric disorders such as schizophrenia frequently exhibit marked sex differences in onset, clinical features, and treatment response. However, the molecular and developmental bases of these differences remain poorly defined. Here, we report a sex-dependent effect of developmental, paralog-selective GSK3B inhibition on working memory (WM) in the Df(16)A
Indexed as
DiGeorge SyndromeGlycogen Synthase Kinase 3 betaMemory, Short-TermTranscriptomeAnimalsDisease Models, AnimalFemaleHippocampusMaleMicePrefrontal CortexSchizophreniaSex CharacteristicsSex FactorsGlycogen Synthase Kinase 3 beta
Identifiers
PMID42276980
PMCPMC13478295
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