Evidence map›Paper›PMID 42276839›Full record

ArticleMolecular pharmaceutics2026

Fluorescence-Guided Surgery of Rhabdomyosarcoma Using a B7-H3 Targeted Antibody-Fluorophore Conjugate.

Ritika Gupta, Evie G Ehrhorn, Ashruti Pant, Samuel S Streeter, Kimberley S Samkoe, Eric R Henderson, Aaron M Mohs

Abstract read
In one paragraph

Article in Molecular pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ritika GuptaDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, 986120 Nebraska Medical Center, Omaha, Nebraska 68198-6858, United States of America.
Evie G EhrhornEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 985950 Nebraska Medical Center, Omaha, Nebraska 68198-6858, United States of America.
Ashruti PantDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, 986120 Nebraska Medical Center, Omaha, Nebraska 68198-6858, United States of America.
Samuel S StreeterThayer School of Engineering, Dartmouth College, 15 Thayer Dr, Hanover, New Hampshire 03755, United States of America.
Kimberley S SamkoeThayer School of Engineering, Dartmouth College, 15 Thayer Dr, Hanover, New Hampshire 03755, United States of America.ORCID 0000-0002-8234-2308
Eric R HendersonThayer School of Engineering, Dartmouth College, 15 Thayer Dr, Hanover, New Hampshire 03755, United States of America.
Aaron M MohsDepartment of Pharmaceutical Sciences, University of Nebraska Medical Center, 986120 Nebraska Medical Center, Omaha, Nebraska 68198-6858, United States of America.ORCID 0000-0002-9353-5404

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
NCI NIH HHS P30 CA036727
6 · The paper itself

Abstract

Resection of sarcomas is often limited by infiltrative tumor growth and microscopic residual disease, underscoring the need for targeted intraoperative imaging strategies that enhance visualization of primary lesions and metastatic deposits. Here, a clinical-grade anti-B7-H3 antibody (MGA271) was conjugated to IRDye 800CW to generate MGA271-IRDye800, with an isotype control IgG-IRDye800 and unconjugated IRDye800 included as comparators. The resulting antibody-dye conjugates, MGA271-IRDye800 and IgG-IRDye800, exhibited an average dye-to-protein ratio of approximately 1.

Indexed as

B7 AntigensFluorescent DyesImmunoconjugatesRhabdomyosarcomaSurgery, Computer-AssistedAnimalsCell Line, TumorFemaleHumansIndolesMiceMice, NudeOptical ImagingB7 AntigensCD276 protein, humanFluorescent DyesImmunoconjugatesIndolesIRDye800Fluorescence Guided SurgeryIntraoperativeMGA271-IRDye800Near-Infrared Fluorescent (NIRF) ImagingNear-Infrared ProbeRhabdomyosarcoma B7-H3Sarcoma

Identifiers

PMID42276839
PMCPMC13501389

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.