ArticleSubstance use & misuse2026
Substance Use and Incidence of Psychosis Diagnoses Among Gay, Bisexual, and Other Men Who Have Sex with Men Compared with Males from the General Population: A Matched Cohort Study from Metro Vancouver, Canada.
Article in Substance use & misuse, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGay, bisexual, and other men who have sex with men (GBM) report higher use of psychoactive substances, which may contribute to many adverse outcomes.
methodWe examined the incidence of psychosis and associated substance use among GBM compared with males from the general male population. We analyzed data from 798 sexually active GBM from two cohort studies based in Vancouver, Canada, linking their survey data to administrative health records. We matched GBM (1:5) by age and geography to HIV-negative males. We determined incident psychosis using ICD-9/10 codes and examined associated factors using Poisson regression.
resultsIncidence was 1.74 per 100 person-years for GBM and 0.64 for their matches (risk-ratio = 2.71; 95% CI:1.95-3.78). Among GBM, opioid use, living with HIV, unstable housing, and anxiety symptoms were independently associated with psychosis.
conclusionsAddressing social determinants of health for GBM such as unstable housing, particularly among those living with HIV, may reduce the burden of substance-use associated psychosis.
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