Evidence map›Paper›PMID 42276732›Full record

ArticleRMD open2026

[

Simon M Petzinna, Jim Küppers, Benedikt Schemmer, Raul N Jamin, Sophie-Marie Kirch, Claus-Jürgen Bauer, Reza Gheitasi, Anna L Kernder, Daniel Ginzburg, Niklas T Baerlecken and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Simon M Petzinna *Medical Clinic and Polyclinic III Internal Medicine with a focus on Oncology, Hematology, and Rheumatology, Germany, University Hospital Bonn, Bonn, Germany simon_michael.petzinna@ukbonn.de.ORCID http://orcid.org/0000-0002-4686-1143
Jim Küppers *Clinic and Polyclinic for Nuclear Medicine, University Hospital Bonn, Bonn, Germany.
Benedikt SchemmerClinic and Polyclinic for Nuclear Medicine, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0009-0007-6827-7187
Raul N JaminUniversity of Bonn, University Hospital Bonn, Medical Clinic and Polyclinic II Internal Medicine with a focus on Cardiology, Angiology and Pneumology, University Hospital Bonn, Bonn, Germany.
Sophie-Marie KirchMedical Clinic and Polyclinic III Internal Medicine with a focus on Oncology, Hematology, and Rheumatology, Germany, University Hospital Bonn, Bonn, Germany.
Claus-Jürgen BauerMedical Clinic and Polyclinic III Internal Medicine with a focus on Oncology, Hematology, and Rheumatology, Germany, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-3152-6550
Reza GheitasiMedical Clinic and Polyclinic III Internal Medicine with a focus on Oncology, Hematology, and Rheumatology, Germany, University Hospital Bonn, Bonn, Germany.
Anna L KernderDepartment of Rheumatology & Hiller-Research Unit Rheumatology, University Hospital of Düsseldorf, Düsseldorf, Germany.ORCID http://orcid.org/0000-0002-7742-7526
Daniel GinzburgClinic and Polyclinic for Nuclear Medicine, University Hospital Bonn, Bonn, Germany.
Niklas T BaerleckenMedical Clinic and Polyclinic III Internal Medicine with a focus on Oncology, Hematology, and Rheumatology, Germany, University Hospital Bonn, Bonn, Germany.
Gustav B JungMedical Clinic and Polyclinic III Internal Medicine with a focus on Oncology, Hematology, and Rheumatology, Germany, University Hospital Bonn, Bonn, Germany.
Maike S AdamsonMedical Clinic and Polyclinic III Internal Medicine with a focus on Oncology, Hematology, and Rheumatology, Germany, University Hospital Bonn, Bonn, Germany.
Markus Essler *Clinic and Polyclinic for Nuclear Medicine, University Hospital Bonn, Bonn, Germany.
Valentin S Schäfer *Medical Clinic and Polyclinic III Internal Medicine with a focus on Oncology, Hematology, and Rheumatology, Germany, University Hospital Bonn, Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAssessing disease activity in giant cell arteritis (GCA) remains challenging, as existing clinical, laboratory and imaging biomarkers lack specificity. This proof-of-concept study explored the diagnostic potential of vascular adhesion protein-1 (VAP-1) targeting [

methodsPatients with newly diagnosed GCA underwent [

resultsEight patients with newly diagnosed GCA were compared with eight relapsing patients, alongside eight controls. Imaging revealed a positive association between ultrasound-assessed subclavian artery intima-media thickness and tracer uptake (r=0.67, p=0.035). Prednisolone exposure was inversely associated with vascular uptake across various vascular regions, with SUVmean showing a stronger overall negative association than SUVmax (SUVmean r=-0.51, p=0.043; SUVmax r=-0.62, p=0.010). Levels of sVAP-1 were reduced in newly diagnosed GCA compared with relapsing patients (p=0.0145) and controls (p=0.0446), and inversely associated with MMP2 (r=-0.56, p=0.037) and MMP9 (r=-0.47, p=0.089). Notably, MMP2 and MMP3 were negatively associated with vascular uptake (eg, aortic arch: r=-0.59, p=0.027).

conclusionsThis first-in-human study demonstrates that [

Indexed as

Antigens, CDGiant Cell ArteritisMolecular ImagingPositron Emission Tomography Computed TomographySialic Acid Binding Immunoglobulin-like LectinsAgedAged, 80 and overAmine Oxidase (Copper-Containing)BiomarkersCell Adhesion MoleculesFemaleGallium RadioisotopesHeterocyclic Compounds, 1-RingHumansInflammationMaleAmine Oxidase (Copper-Containing)Antigens, CDAOC3 protein, humanBiomarkersCell Adhesion MoleculesGallium RadioisotopesHeterocyclic Compounds, 1-RingRadiopharmaceuticalsSialic Acid Binding Immunoglobulin-like LectinsBiomarkersGiant Cell ArteritisInflammationPolymyalgia RheumaticaVasculitis

Identifiers

PMID42276732
PMCPMC13295787

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.