Evidence map›Paper›PMID 42276726›Full record

ReviewClinics in perinatology2026

Evaluation and Management of Genetic Respiratory Disorders Presenting as Hypoxemic Respiratory Failure in the Newborn Infant.

Jennifer A Wambach, F Sessions Cole, Lawrence M Nogee

Abstract readReview
In one paragraph

Review in Clinics in perinatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jennifer A WambachEdward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, 660 South Euclid Avenue, St Louis, MO 63110, USA. Electronic address: wambachj@wustl.edu.
F Sessions ColeEdward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis Children's Hospital, 660 South Euclid Avenue, St Louis, MO 63110, USA.
Lawrence M NogeeDepartment of Pediatrics, Johns Hopkins University, 1800 Orleans Street, Suite 8530, Baltimore, MD 21287, USA.

Funding

Diagnosing the Unknown for Care and Advancing Science (DUCAS)U2CNS132415 · NINDS · HARVARD MEDICAL SCHOOL · PI Francis Sessions Cole · 2023 to 2026
$32.1M
Functional Characterization of ABCA3 Genomic VariantsR01HL149853 · NHLBI · WASHINGTON UNIVERSITY · PI Jennifer Wambach · 2020 to 2026
$3.9M
High-Content Analysis to Accelerate Mechanistic and Therapeutic Identification for ABCA3 DeficiencyR03TR004845 · NCATS · WASHINGTON UNIVERSITY · PI WAMBACH, JENNIFER · 2025 to 2025
$156k
NCATS NIH HHS R03 TR004845NHLBI NIH HHS R01 HL149853NINDS NIH HHS U2C NS132415
6 · The paper itself

Abstract

Hypoxemic respiratory failure is a common reason for admission to the neonatal intensive care unit for term and late preterm infants. Some infants have rare disorders due to genetic mechanisms including surfactant dysfunction disorders, alveolar capillary dysplasia with misalignment of the pulmonary veins, and other developmental lung disorders that result in more severe, persistent, and even fatal disease. In this article, we summarize clinical characteristics of the most common causes of neonatal respiratory failure and of rare genetic causes, to help clinicians differentiate between common and rare causes and to aid in clinical decision-making including timing of genetic testing.

Indexed as

Hypertension, PulmonaryHypoxiaLung Diseases, InterstitialRespiratory InsufficiencyATP-Binding Cassette TransportersGenetic TestingHernia, DiaphragmaticHernias, Diaphragmatic, CongenitalHumansHyaline Membrane DiseaseInfant, NewbornPersistent Fetal Circulation SyndromePulmonary Alveolar ProteinosisPulmonary AlveoliPulmonary Surfactant-Associated Protein CPulmonary Surfactant-Associated ProteinsABCA3 protein, humanATP-Binding Cassette TransportersPulmonary Surfactant-Associated Protein CPulmonary Surfactant-Associated ProteinsSFTPC protein, humanABCA3Childhood interstitial lung diseaseFOXF1Neonatal respiratory failurePulmonary hypertensionSFTPBSFTPCTBX4

Identifiers

PMID42276726
PMCPMC13353067

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.