Evidence map›Paper›PMID 42276723›Full record

ReviewClinics in perinatology2026

Management of Hypoxemic Respiratory Failure in the Newborn During Therapeutic Hypothermia.

Paulina Hume, Luna Khanal, Satyan Lakshminrusimha, Deepika Sankaran

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Clinics in perinatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Paulina HumeDivision of Neonatology, Department of Pediatrics, University of California, Davis, 2516 Stockton Boulevard, Sacramento, CA 95817, USA.
Luna KhanalDivision of Neonatology, Department of Pediatrics, University of California, Davis, 2516 Stockton Boulevard, Sacramento, CA 95817, USA.
Satyan LakshminrusimhaDivision of Neonatology, Department of Pediatrics, University of California, Davis, 2516 Stockton Boulevard, Sacramento, CA 95817, USA.
Deepika SankaranDivision of Neonatology, Department of Pediatrics, University of California, Davis, 2516 Stockton Boulevard, Sacramento, CA 95817, USA. Electronic address: dsankaran@health.ucdavis.edu.

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
Institutional Career Development Core (KL2)KL2TR001859 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HOLMES, JAMES F. · 2016 to 2025
$10.1M
Optimal Oxygenation in Neonatal Lung InjuryR01HD072929 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Satyanarayana Lakshminrusimha · 2012 to 2026
$5.4M
OPTImal vasoPRESsor in persistent pulmonary hypertension of the newborn (OPTIPRES)K08HL181183 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Deepika Sankaran · 2025 to 2026
$330k
Neonatal Hypovolemic Cardiac Arrest: Role of Early Rapid Volume ResuscitationR03HD109443 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SANKARAN, DEEPIKA · 2023 to 2023
$160k
NCATS NIH HHS KL2 TR001859NCATS NIH HHS UL1 TR001860NHLBI NIH HHS K08 HL181183NICHD NIH HHS R01 HD072929NICHD NIH HHS R03 HD109443
6 · The paper itself

Abstract

Therapeutic hypothermia (TH) is the gold standard for the management of hypoxic ischemic encephalopathy (HIE) in newborns. Both hypoxia and TH may contribute to an increase in pulmonary vascular resistance (PVR), resulting in persistent pulmonary hypertension of the newborn. Infants with worsening hypoxemic respiratory failure in the setting of HIE and TH may require optimization of respiratory support to achieve adequate lung recruitment, surfactant, and inhaled nitric oxide to improve oxygenation and ventilation strategies to avoid acidosis and hypocapnia. Furthermore, management of systemic hypotension should be tailored to increase systemic vascular resistance without increasing PVR.

Indexed as

Hypothermia, InducedHypoxiaHypoxia-Ischemia, BrainPersistent Fetal Circulation SyndromeRespiratory InsufficiencyHumansHypertension, PulmonaryInfant, NewbornNitric OxidePulmonary SurfactantsVascular ResistanceNitric OxidePulmonary SurfactantsHypothermiaHypoxic ischemic encephalopathyHypoxic respiratory failurePersistent pulmonary hypertension of the newborn

Identifiers

PMID42276723
PMCPMC13452473

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.