HDAC4 regulates hASC osteogenesis and bone regeneration by mediating SMAD4 via histone acetylation.

Liyuan Yu, Kai Xia, Yijue Wang, Zhiai Hu, Jun Liu, Shujuan Zou, Jianwei Chen

Abstract read

In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

7 authors.

Liyuan YuState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610106, P.R. China; Centre of Craniofacial Orthodontics, Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, P.R. China.

Kai XiaState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610106, P.R. China; Center Laboratory of Dental Biomaterials and Tissue Regeneration, Shanghai Xuhui District Stomatological Hospital, Shanghai 200032, P.R. China.

Yijue WangState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610106, P.R. China.

Zhiai HuState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610106, P.R. China.

Jun LiuState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610106, P.R. China.

Shujuan ZouState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610106, P.R. China.

Jianwei ChenState Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610106, P.R. China. Electronic address: chenjianwei2017@vip.163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Craniofacial large bone defects possess limited self-repair capacity. This study identifies histone deacetylase 4 (HDAC4) as a key epigenetic repressor of osteogenesis in human adipose-derived stem cells. Inhibiting HDAC4, either genetically or pharmacologically with tasquinimod, enhanced histone acetylation and activates SMAD4 expression, thereby promoting bone formation. A sustained-release hydrogel delivering tasquinimod was developed and demonstrated to significantly enhance bone regeneration in critical-sized cranial and mandibular defects in mice. The findings reveal a promising localized epigenetic strategy for repairing craniofacial bone defects.

Indexed as

Bone RegenerationHistone DeacetylasesHistonesOsteogenesisRepressor ProteinsSmad4 ProteinAcetylationAnimalsCell DifferentiationHumansMiceHDAC4 protein, humanHistone DeacetylasesHistonesRepressor ProteinsSmad4 Proteinbone remodelinghistone deacetylase 4osteogenic differentiationstem cellstasquinimod

Identifiers

PMID42276061

DOI10.1016/j.stemcr.2026.102955

PMCPMC13385728

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.