Evidence map›Paper›PMID 42276053›Full record

ArticleCell reports. Medicine2026

Patient-derived organoids predict personalized drug response and reveal alternative therapeutic options in glioblastoma.

Jisu Park, Meiyu Qiu, Eun Jeong Cho, Sanghee Seo, Ji-Hoon Moon, Minji Kim, Hyemin Mun, Hyounji Yun, Hoewon Park, Arim Lim and 14 more

Abstract read
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Jisu ParkGraduate School of Stem Cell and Regeneration Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.
Meiyu QiuDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.
Eun Jeong ChoSG BioScience, Inc., Seoul 02637, Republic of Korea.
Sanghee SeoDepartment of Biological Sciences, Chungnam National University, Daejeon 34134, Republic of Korea.
Ji-Hoon MoonDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.
Minji KimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.
Hyemin MunSG BioScience, Inc., Seoul 02637, Republic of Korea.
Hyounji YunDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.
Hoewon ParkDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.
Arim LimDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea.
Younsoo KangSG BioScience, Inc., Seoul 02637, Republic of Korea; Department of Medical Science, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
Jeong-Woo OhSG BioScience, Inc., Seoul 02637, Republic of Korea.
Heejeong YoukSG BioScience, Inc., Seoul 02637, Republic of Korea.
Seon-Hwan KimDepartment of Neurosurgery, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.
Yeongbeom SeoDepartment of Neurosurgery, Yeungnam University Hospital, Yeungnam University School of Medicine, Daegu 42415, Republic of Korea.
Sae Min KwonDepartment of Neurosurgery, Dongsan Medical Center, Keimyung University School of Medicine, Daegu 41931, Republic of Korea.
Kyoung Su SungDepartment of Neurosurgery, Dong-A University Hospital, Dong-A University, College of Medicine, Busan 49201, Republic of Korea.
Hyuk-Jin OhDepartment of Neurosurgery, Soonchunhyang University Hospital Cheonan, Soonchunhyang University School of Medicine, Cheonan 31151, Republic of Korea.
Kyung Rae ChoDepartment of Neurosurgery, Konkuk University Medical Center, Seoul 05030, Republic of Korea.
Kyungtae YoonDepartment of Biological Sciences, Chungnam National University, Daejeon 34134, Republic of Korea.
Nam-Shik KimDepartment of Biological Sciences, Chungnam National University, Daejeon 34134, Republic of Korea. Electronic address: nskim1@cnu.ac.kr.
Se Jin JangSG BioScience, Inc., Seoul 02637, Republic of Korea; Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea. Electronic address: jangsejin@amc.seoul.kr.
Kyung Hwan KimDepartment of Neurosurgery, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea. Electronic address: lastbreak0@gmail.com.
Ki-Jun YoonDepartment of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; Graduate School of Stem Cell and Regeneration Biology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Stem Cell Center, KAIST, Daejeon 34141, Republic of Korea. Electronic address: kijunyoon@kaist.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastoma remains a highly aggressive brain tumor with limited treatment options and poor prognosis. Temozolomide (TMZ) is the only approved first-line therapy, but frequent resistance limits its efficacy, highlighting the urgent need for alternative treatments. We establish 18 glioblastoma organoid (GBO) lines that preserve the histopathological and genomic features of the parental tumors, enabling comparison with clinical outcomes. GBO-based drug sensitivity testing (GBO-DST) showed a strong correlation with progression-free survival and outperformed O

Indexed as

Brain NeoplasmsGlioblastomaOrganoidsPrecision MedicineAnimalsCell Line, TumorDNA Modification MethylasesDNA Repair EnzymesDrug Resistance, NeoplasmFemaleGene Expression Regulation, NeoplasticHumansMiceTemozolomideTumor Suppressor ProteinsXenograft Model Antitumor AssaysDNA Modification MethylasesDNA Repair EnzymesTemozolomideTumor Suppressor Proteinsglioblastomalazertiniborganoid-based drug screeningpatient-derived organoidpersonalized medicineprecision oncologytemozolomide resistance

Identifiers

PMID42276053
PMCPMC13400186

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.