ReviewCurrent opinion in genetics & development2026
Reassessing forebrain organization: recent evidence challenges the prosomere model.
Review in Current opinion in genetics & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
For over three decades, the prosomere model has influenced our understanding of vertebrate brain development by proposing that the forebrain consists of several transverse segments, termed prosomeres. However, advances in molecular genetics and imaging have challenged key assumptions of this model, including the existence of clear segmental boundaries and the positioning of forebrain axes. Here we critically review evidence from gene expression, fate-mapping, and morphogenesis studies, finding limited support for prosomeric segmentation and questioning the grouping of the hypothalamus with the telencephalon. We propose the tripartite hypothalamus model as an alternative framework that better aligns with recent data, restoring the hypothalamus's relationship to the diencephalon and recognizing the anterior forebrain as a uniquely complex, non-segmented unit with a posterior boundary within the diencephalon. These findings suggest a need to revise our understanding of forebrain structure, patterning, and evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.