Evidence map›Paper›PMID 42275502›Full record

ArticleScience (New York, N.Y.)2026

Long-term isolation and archaic introgression shape functional genetic variation in Near Oceania.

Patrick F Reilly, Stephen Rong, Daniela Tejada-Martinez, Samantha L Miller, Audrey Tjahjadi, Chang Liu, Jared Akers, Alysa Pomer, Margaret E Prentice, D Andrew Merriwether and 5 more

Abstract read
In one paragraph

Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Patrick F ReillyDepartment of Anthropology, Yale University, New Haven, CT, USA.ORCID 0000-0003-3468-9769
Stephen RongDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6584-1391
Daniela Tejada-MartinezDepartment of Anthropology, Yale University, New Haven, CT, USA.ORCID 0000-0001-9531-5280
Samantha L MillerDepartment of Anthropology, Yale University, New Haven, CT, USA.ORCID 0000-0002-3001-2614
Audrey TjahjadiDepartment of Anthropology, Yale University, New Haven, CT, USA.ORCID 0000-0001-5586-1973
Chang LiuDepartment of Anthropology, Yale University, New Haven, CT, USA.ORCID 0000-0002-4585-5809
Jared AkersDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-9270-0017
Alysa PomerDepartment of Anthropology, Yale University, New Haven, CT, USA.ORCID 0000-0003-1267-1189
Margaret E PrenticeDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.ORCID 0009-0001-2033-1080
D Andrew MerriwetherDepartment of Anthropology, Binghamton University, Binghamton, NY, USA.ORCID 0000-0001-9792-1508
Françoise R FriedlaenderDepartment of Anthropology, Temple University, Philadelphia, PA, USA.
George KokiPapua New Guinea Institute for Medical Research, Goroka, East Highlands Province, Papua New Guinea.
Jonathan S FriedlaenderDepartment of Anthropology, Temple University, Philadelphia, PA, USA.
Steven K ReillyDepartment of Genetics, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3140-1483
Serena TucciDepartment of Anthropology, Yale University, New Haven, CT, USA.ORCID 0000-0001-7255-0691

Funding

Multi-scale functional dissection and modeling of regulatory variation associated with human traitsR01HG012872 · NHGRI · YALE UNIVERSITY · PI Steven K. Reilly · 2023 to 2026
$3.1M
Mapping the Full Spectrum of Human Genetic Variation and Archaic Hominin Introgression in OceaniaR35GM147565 · NIGMS · YALE UNIVERSITY · PI Serena Tucci · 2022 to 2026
$2.2M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
Comprehensive Characterization of Adaptive Regulatory Variation Linked to Human DiseaseR00HG010669 · NHGRI · YALE UNIVERSITY · PI REILLY, STEVEN K. · 2021 to 2023
$737k
NHGRI NIH HHS R00 HG010669NHGRI NIH HHS R01 HG012872NIGMS NIH HHS R35 GM147565NIH HHS S10 OD030363
6 · The paper itself

Abstract

Near Oceanic populations harbor substantial cultural, phenotypic, and genetic diversity yet are drastically underrepresented in human genomics. We generated 177 high-coverage Near Oceanian whole genomes and analyzed them alongside 1284 worldwide genomes, revealing major distinctions among and within islands, including long-term isolation and strong population bottlenecks. We reconstructed 1.897 billion base pairs of the archaic genome, including 831.9 million base pairs of Denisovan sequence, and found evidence for introgression from three Denisovan-like groups in Near Oceanians and adaptive Denisovan introgression at

Indexed as

Genetic IntrogressionGenetic VariationGenome, HumanOceaniansReproductive Isolation2',5'-Oligoadenylate SynthetaseGTP-Binding ProteinsHumansInterferon-gammaJanus Kinase 1OceaniaSignal Transduction2',5'-Oligoadenylate SynthetaseGTP-Binding ProteinsInterferon-gammaJanus Kinase 1

Identifiers

PMID42275502
PMCPMC13362234

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.