Evidence map›Paper›PMID 42275500›Full record

ArticleScience (New York, N.Y.)2026

Placental nicotinamide adenine dinucleotide modulates the timing of labor.

Erin J Ciampa, Luana M Machado, Kathy J Lee, Amanda J Clark, Kyle Q Vu, Nawal A Khan, Sarah Kispert, Samantha Armstrong, Yunping Li, Ginger L Milne and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Erin J CiampaDepartment of Anesthesia, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0002-6153-1994
Luana M MachadoDepartment of Anesthesia, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0009-0006-9455-4718
Kathy J LeeDepartment of Anesthesia, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Amanda J ClarkDepartment of Pediatrics, University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, TX, USA.ORCID 0000-0002-6550-730X
Kyle Q VuDepartment of Pediatrics, University of Texas Southwestern Medical Center and Children's Medical Center, Dallas, TX, USA.ORCID 0009-0000-7439-1786
Nawal A KhanCecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0009-0002-7049-9284
Sarah KispertDepartment of Anesthesia, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0009-0009-8521-7041
Samantha ArmstrongDepartment of Anesthesia, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0009-0005-0283-3772
Yunping LiDepartment of Anesthesia, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID 0000-0002-1399-5241
Ginger L MilneDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-3890-151X
Ashley SolmonsonCecil H. and Ida Green Center for Reproductive Biology Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0001-8863-4558
S Ananth KarumanchiDepartment of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0002-2281-6831
Samir M ParikhDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1038-981X

Funding

UT Southwestern NORCP30DK127984 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI JONATHAN Charles COHEN · 2022 to 2026
$7.4M
The Aging Kidney: Chronic Injury, Impaired Functions and Clinical OutcomesR01AG027002 · NIA · TUFTS MEDICAL CENTER · PI PARIKH, SAMIR M, SARNAK, MARK J · 2005 to 2022
$7.3M
Mitochondrial Biogenesis in Kidney DiseaseR01DK095072 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Samir M Parikh · 2012 to 2026
$5.3M
Placental NAD and its effect on labor onsetK08HD117001 · NICHD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Erin Julia Ciampa · 2025 to 2026
$329k
NIA NIH HHS R01 AG027002NICHD NIH HHS K08 HD117001NIDDK NIH HHS P30 DK127984NIDDK NIH HHS R01 DK095072
6 · The paper itself

Abstract

Labor is mediated proximately by prostaglandin signaling within gestational tissues and must be tightly regulated for birth to occur after appropriate fetal development. Metabolic changes accompanying gestational aging have been postulated as a determinant of birth timing, but specific nutrients, sensors, and messengers remain obscure. We report that placental nicotinamide adenine dinucleotide (NAD

Indexed as

Hydroxyprostaglandin DehydrogenasesLabor OnsetNADObstetric Labor, PrematurePlacentaAlcohol OxidoreductasesAnimalsFemaleGestational AgeMiceMice, Inbred C57BLModels, AnimalPregnancyProstaglandins15-hydroxyprostaglandin dehydrogenaseAlcohol OxidoreductasesHydroxyprostaglandin DehydrogenasesNADProstaglandins

Identifiers

PMID42275500
PMCPMC13555591

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.