Evidence map›Paper›PMID 42275444›Full record

ArticleJMIR research protocols2026

Safety and Effectiveness of an Integrative Treatment of Acupuncture-Based Intervention in Survivors of Breast Cancer With Postmastectomy Pain Syndrome: Protocol for a Single-Center, Single-Arm Exploratory Trial.

Naruaki Kawasaki, Hiroto Ishiki, Naho Matsubara, Takako Ikegami, Ayaka Ishikawa, Sayaka Arakawa, Asuka Takahashi, Tomoko Uchida, Yukie Nameki, Yoko Horiguchi and 10 more

Abstract readClinical Trial Protocol
In one paragraph

Article in JMIR research protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Naruaki KawasakiDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 1040045, Japan, 81 335422511.ORCID 0000-0003-1245-2293
Hiroto IshikiDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 1040045, Japan, 81 335422511.ORCID 0000-0002-0800-2161
Naho MatsubaraDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 1040045, Japan, 81 335422511.ORCID 0000-0003-4354-3497
Takako IkegamiDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 1040045, Japan, 81 335422511.ORCID 0009-0004-0808-3506
Ayaka IshikawaDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 1040045, Japan, 81 335422511.ORCID 0009-0005-4004-554X
Sayaka ArakawaDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 1040045, Japan, 81 335422511.ORCID 0009-0001-3844-2512
Asuka TakahashiDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 1040045, Japan, 81 335422511.ORCID 0009-0000-3185-3266
Tomoko UchidaDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 1040045, Japan, 81 335422511.ORCID 0009-0000-5509-4022
Yukie NamekiDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 1040045, Japan, 81 335422511.ORCID 0009-0000-5150-4936
Yoko HoriguchiDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 1040045, Japan, 81 335422511.ORCID 0009-0000-4273-0608
Takeshi MurataDepartment of Breast Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.ORCID 0000-0003-0942-7599
Shin TakayamaDepartment of Breast Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.ORCID 0000-0001-7210-0922
Akihiko SutoDepartment of Breast Surgery, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.ORCID 0000-0003-1458-2593
Kota KiharaJapanese Organisation for Research and Treatment of Cancer, Arakawa-ku, Tokyo, Japan.ORCID 0000-0002-1781-2983
Keisuke AriyoshiJapanese Organisation for Research and Treatment of Cancer, Arakawa-ku, Tokyo, Japan.ORCID 0009-0002-8896-2572
Shunsuke OyamadaJapanese Organisation for Research and Treatment of Cancer, Arakawa-ku, Tokyo, Japan.ORCID 0000-0002-8130-6815
Ayako KayanoDepartment of Psycho-Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.ORCID 0009-0008-6512-5740
Hiromichi MatsuokaDepartment of Psycho-Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan.ORCID 0000-0002-7276-1971
Tatsuya TakagiDepartment of Palliative Medicine, Graduate School of Medicine, Juntendo University, Bunkyo-ku, Tokyo, Japan.ORCID 0000-0002-9345-9544
Eriko SatomiDepartment of Palliative Medicine, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo, 1040045, Japan, 81 335422511.ORCID 0000-0003-1516-2849

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Postmastectomy pain syndrome (PMPS) is a prevalent chronic pain condition that occurs after breast cancer surgery, often impairing quality of life in survivors of breast cancer. Despite its prevalence, no standardized treatment has been established. Acupuncture has been reported to be an efficacious intervention for the management of chronic pain and may be an effective treatment for PMPS. Objective: This study aims to explore the effectiveness and safety of integrative treatment of acupuncture-based intervention for PMPS. Methods: This is a single-center, single-arm, prospective interventional study. Eligible participants are patients with breast cancer who experience chronic postoperative pain in the chest, neck, or shoulder with a numerical rating scale (NRS) score ≥4, are at least 6 months postcurative treatment, have no evidence of disease recurrence, and are not receiving anticancer treatment at enrollment. Participants will receive the intervention once weekly for 12 sessions, followed by a 4-week observation period. The primary end point is the change in the average pain NRS score from baseline to week 16. Results: The study commenced in October 2023 and is scheduled to continue through March 31, 2027. The first participant was enrolled on October 24, 2023. As of the manuscript submission, 24 patients have been enrolled. Conclusions: This study will explore the potential role of an integrative treatment of acupuncture-based intervention in the management of PMPS. The results will contribute to the evidence base for acupuncture in PMPS and inform the design of future clinical studies.

Indexed as

Acupuncture TherapyBreast NeoplasmsMastectomyPostoperative PainAdultCancer SurvivorsFemaleHumansMiddle AgedPain MeasurementProspective StudiesQuality of LifeTreatment Outcomeacupuncturebreast cancer survivorshipchronic painpostmastectomy pain syndromestudy protocol

Identifiers

PMID42275444
PMCPMC13256498

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.