ArticlePloS one2026
ZIF-8-coated 3D-printed PCL/ion-doped BCP scaffolds for enhanced bone regeneration.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- First-Digit Distributions of Human Long-Bone Morphometric Parameters: An Exploratory X-Ray-Based Comparison with Benford's Law.International journal of general medicine · 2026Article
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Authors and funding
5 authors.
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Abstract
Large bone defects require bioactive, mechanically robust scaffolds for regeneration. This study developed 3D-printed polycaprolactone/biphasic calcium phosphate (PCL/BCP) composite scaffolds (35-45 wt% ion-doped BCP with Sr2+, Mg2+, and Si4+) via fused deposition modeling (FDM), followed by in situ ZIF-8 coating. The optimal PCL + 40 wt.% ion-doped BCP formulation exhibited superior compressive strength (~30 MPa) and modulus (~ 0.4 GPa). Degradation in Phosphate-buffered saline (PBS) showed ~8% mass loss over 28 days with stable pH. Immersion in simulated body fluid (SBF) revealed rapid apatite formation and sustained release of Ca2+, P, Mg2+, Si4+, and Sr2+ ions. SEM confirmed uniform nanoscale ZIF-8 deposition, enriching surfaces with Zn2+. In vitro assays with MG-63 cells and hBMSCs demonstrated that ZIF-8-coated scaffolds significantly enhanced cell adhesion, proliferation (MTT), cytoskeletal organization (DAPI/phalloidin), and mineralization (Alizarin Red S) compared to uncoated controls (p < 0.05). The synergistic integration of ion-doped BCP, 3D printing, and ZIF-8 coating yields a bioactive, biodegradable platform with excellent osteogenic potential for advanced bone tissue engineering.
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