ArticleAnnals of medicine2026
Associations of atherogenic index of plasma related indices with subclinical carotid atherosclerosis.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEvidence regarding the relationships between atherogenic index of plasma (AIP)-related indices and carotid atherosclerosis (CA) is limited.
methodsA total of 59123 participants from the China Stroke High-risk Population Screening and Intervention Program (CSHPSIP) in Hubei Province, China, from 2017 to 2020 were included in this cross-sectional study. Three indices were developed to assess AIP-related indices: AIP-body mass index (AIP-BMI), AIP-waist circumference (AIP-WC), and AIP-waist-height ratio (AIP -WHtR).
resultsPer 1-standard deviation (SD) increase in AIP-BMI (OR = 1.36, 95% CI = 1.31-1.41), AIP-WC (1.34, 1.29-1.38), and AIP-WHtR (1.33, 1.28-1.38) were associated with CIMT. Per 1-standard deviation (SD) increase in AIP-BMI (OR = 1.32, 95% CI = 1.28-1.37), AIP-WC (1.34, 1.29-1.38), and AIP-WHtR (1.33, 1.29-1.38) were associated with plaques. AIP-BMI, AIP-WC and AIP-WHtR were positively associated with stenosis when they were divided into interquartile range (IQR), compared with the Q1 group. The ROC analyses showed that AIP-BMI had the greatest diagnostic value for CA and CIMT, with the AUC of 0.833 (0.828, 0.838) and 0.817 (0.811, 0.824), respectively. AIP-BMI, AIP-WC and AIP-WHtR had the greatest diagnostic value for plaques, with the AUC of 0.842 (0.836, 0.848), 0.842 (0.836, 0.847), and 0.842 (0.836, 0.848), respectively. Meanwhile, all the four indices (AIP, AIP-BMI, AIP-WC and AIP-WHtR) showed the same diagnostic value for plaques, with the AUC of 0.871 (0.858, 0.884).
conclusionsAIP-related indices were positively associated with CA, carotid intima-media thickness (CIMT), plaque and stenosis. Future prospective studies are needed to confirm our findings and clarify their clinical utility.
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