Evidence map›Paper›PMID 42275251›Full record

ArticleBlood2026

Antifibrinolytic strategies improve liver regeneration in mice and reduce posthepatectomy liver failure in patients.

Zhihao Li, Zimu Wei, Dafna J Groeneveld, Amy W Strilchuk, Matthew J Flick, Yawen Dong, Vanja Podrascanin, Mark J Truty, Michael L Kendrick, Sean P Cleary and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zhihao LiDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.ORCID 0000-0002-5654-7043
Zimu WeiPathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI.ORCID 0000-0002-2944-3118
Dafna J GroeneveldPathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI.ORCID 0000-0002-1207-5769
Amy W StrilchukMichael Smith Laboratories, University of British Columbia, Vancouver, Canada.
Matthew J FlickDepartment of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Yawen DongDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.ORCID 0000-0002-3631-1228
Vanja PodrascaninDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.
Mark J TrutyDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.
Michael L KendrickDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.
Sean P ClearyDivision of General Surgery, University Health Network, University of Toronto, Toronto, Canada.
Susanne G WarnerDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.
Rory L SmootDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.ORCID 0000-0001-8543-661X
Alice AssingerCenter of Physiology and Pharmacology, Institute of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria.
Christian J KastrupVersiti Blood Research Institute, Milwaukee, WI.ORCID 0000-0003-3644-0019
Paul KaranicolasDivision of General Surgery, Sunnybrook Health Sciences Centre, Toronto, Canada.
James P LuyendykPathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI.ORCID 0000-0003-3174-8583
Patrick P StarlingerDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, Mayo Clinic, Rochester, MN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractPharmacological plasminogen reduction enhanced liver regeneration experimentally and clinically. Small interfering RNA-induced plasminogen deficiency promoted hepatocyte proliferation after partial hepatectomy in mice, contrasting genetic deficiency models. In the HeLiX trial, tranexamic acid reduced posthepatectomy liver failure odds, suggesting a novel therapeutic strategy.

Indexed as

Antifibrinolytic AgentsHepatectomyLiver FailureLiver RegenerationTranexamic AcidAnimalsCell ProliferationHepatocytesHumansMicePlasminogenRNA, Small InterferingAntifibrinolytic AgentsPlasminogenRNA, Small InterferingTranexamic Acid

Identifiers

PMID42275251
PMCPMC13588734

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.