ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2026
Wnt regulates cellular differentiation and retinoid metabolism genes in the mouse stomach.
Elizabeth Delgado, Elise S Hibdon, Theresa M Keeley, Christopher Quoc Huynh, Justin A Colacino, Linda C Samuelson
Abstract read
In one paragraphArticle in American journal of physiology. Gastrointestinal and liver physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Elizabeth DelgadoDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Elise S HibdonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Theresa M KeeleyDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Christopher Quoc HuynhDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.
Justin A ColacinoDepartment of Environmental Health Sciences, University of Michigan, Ann Arbor, Michigan, United States.
Linda C SamuelsonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, United States.ORCID 0000-0002-0898-2243 Funding
MICHIGAN MEDICAL SCIENTIST TRAINING PROGRAMT32GM007863 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI COLLINS, KATHLEEN L. · 1985 to 2024
$38.3MStrategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3MUniversity of Michigan Postbaccalaureate Research Education Program (UM PREP)R25GM086262 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN · 2009 to 2024
$6.1MDiversity SupplementR01ES028802 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Justin Adam Colacino · 2018 to 2026
$4.8MTraining in Basic and Translational Digestive SciencesT32DK094775 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN Y KAO, LINDA C. SAMUELSON · 2012 to 2026
$3.6MWnt Pathway Regulation of Gastric Stem Cell FunctionR01DK126451 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAMUELSON, LINDA C. · 2022 to 2025
$2.0MWnt-Retinoic Acid Regulation of Gastric Epithelial CellsR01DK142725 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LINDA C. SAMUELSON · 2025 to 2026
$1.2MTargeting cancer stem-like cells and inflammation for colon cancer chemopreventionR21CA273646 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, GRACE Y., COLACINO, JUSTIN ADAM · 2023 to 2024
$392kWnt pathway regulation of human gastric stem cell functionK01DK111710 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HIBDON, ELISE · 2017 to 2018
$183kHHS | NIH | National Cancer Institute (NCI) R21-CA273646HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01-DK126451HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01-DK142725HHS | NIH | National Institute of Environmental Health Sciences (DEHS) P30-ES017885HHS | NIH | National Institute of Environmental Health Sciences (DEHS) R01-ES028802HHS | NIH | National Institute of General Medical Sciences (NIGMS) R25-GM086262HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32-GM007863HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) K01-DK111710HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) T32-DK094775NCI NIH HHS R21 CA273646NIDDK NIH HHS K01 DK111710NIDDK NIH HHS R01 DK126451NIDDK NIH HHS R01 DK142725NIDDK NIH HHS T32 DK094775NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES028802NIGMS NIH HHS R25 GM086262NIGMS NIH HHS T32 GM007863
6 · The paper itselfAbstract
Although recognized as a key regulator of gastrointestinal tissues, Wnt signaling pathway function in the stomach is poorly understood. This study aimed to define Wnt functions and identify Wnt-regulated genes in the stomach. Reporter mouse analysis localized Wnt signaling to the base and proliferative region in both the corpus and the antrum. Canonical Wnt inhibition in vivo using
Indexed as
Cell DifferentiationGastric MucosaRetinoidsStomachWnt ProteinsWnt Signaling PathwayAlcohol OxidoreductasesAnimalsbeta CateninCell ProliferationMiceOrganoidsTretinoinAlcohol Oxidoreductasesbeta CateninRetinoidstrans-retinol dehydrogenaseTretinoinWnt Proteinschief cellsgastric organoidsgastric stem cellsretinoic acid signaling
Identifiers
PMID42275232
PMCPMC13417362
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