ArticleACS chemical biology2026
Stability-Based Proteomic Methods Add Value to Activity-Based Protein Profiling Studies.
Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Covalent inhibitors offer powerful therapeutic advantages over noncovalent inhibitors, but like noncovalent inhibitors, they require comprehensive profiling to define their on- and off-target activities. Here, we report on the use of two stability-based proteomic methods, stability of proteins from rates of oxidation (SPROX) and thermal protein profiling (TPP), to identify protein targets of covalent inhibitors using the KRAS
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