ArticleClinical research in cardiology : official journal of the German Cardiac Society2026
Prognostic impact of iliofemoral access-site calcification volume on outcomes after transcatheter aortic valve implantation.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundTranscatheter aortic valve implantation (TAVI) is increasingly performed in patients at low and intermediate risk, emphasizing the need for accurate long-term risk stratification. Although iliofemoral calcification influences procedural planning, its prognostic relevance beyond peri-procedural complications remains uncertain.
objectivesTo evaluate the prognostic value of quantitatively assessed iliofemoral access-site calcification (IASC) for outcomes after TAVI.
methodsThe study included 1067 patients undergoing TAVI. Pre-procedural computed tomography (CT) was used to quantify IASC-volume along the transfemoral access route. Patients were stratified according to the median IASC-volume, and outcomes were compared using propensity score matching (PSM). The primary endpoint was all-cause mortality at 1, 3, and 5 years. Secondary endpoints included peri-procedural complications at 30 days.
resultsThe median IASC-volume was 907 (356-1839) mm
conclusionCT-derived IASC-volume is associated with mid- and long-term mortality after TAVI, without affecting short-term or procedural outcomes. These findings suggest that IASC-volume reflects systemic disease burden and may provide incremental prognostic information beyond established risk scores.
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