ReviewDie Ophthalmologie2026
[Anti-infectious cross-linking: when and how? : PACK-CXL as treatment option for infectious keratitis].
Review in Die Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfectious keratitis remains a major cause of blindness worldwide. Conventional antimicrobial treatment is not always sufficient, particularly against drug-resistant pathogens. Photoactivated chromophore for keratitis-corneal cross-linking (PACK-CXL) offers a promising adjunctive or alternative treatment.
methodsNarrative review based on the current literature and clinical experience, covering mechanisms of action, clinical evidence, protocol selection and practical decision-making criteria for PACK-CXL.
resultsThe PACK-CXL acts via three mechanisms: direct killing of pathogens through reactive oxygen species (ROS), increased resistance to protease digestion through steric hindrance and anti-inflammatory effects. Clinical studies demonstrated that adjuvant PACK-CXL shortens the healing time and as monotherapy achieves approximately 89% success in small bacterial ulcers. Higher total radiation doses (high fluence, ≥ 7.2 J/cm
conclusionThe use of PACK-CXL enables rapid, largely pathogen-independent treatment of infectious keratitis. Protocol selection should be guided by ulcer size, depth and pathogen type. Accelerated high-fluence protocols are particularly suitable for antimicrobial use.
Indexed as
Identifiers
42274734What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.