Evidence map›Paper›PMID 42274715›Full record

ArticleOphthalmic surgery, lasers & imaging retina2026

Effect of Optical Coherence Tomography Angiography Image Artifacts on Quantitation of Vessel Density and Perfusion.

Anna Tang, Ana D Collazo Martinez, Minsoo Kim, Anoush Shahidzadeh, Shu Jie Ting, Brinda Vaidya, Xuejuan Jiang, Hoan V Le, Ruikang Wang, Alexa Beiser and 3 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmic surgery, lasers & imaging retina, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna Tang *Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
Ana D Collazo Martinez *Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
Minsoo KimDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.
Anoush ShahidzadehDepartment of Ophthalmology, Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California.
Shu Jie TingThe Framingham Heart Study, Framingham.
Brinda VaidyaThe Framingham Heart Study, Framingham.
Xuejuan JiangDepartment of Ophthalmology, Roski Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California.
Hoan V LeDepartment of Bioengineering.
Ruikang WangDepartment of Bioengineering.
Alexa BeiserThe Framingham Heart Study, Framingham.
Lucia SobrinDepartment of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts.
Sudha SeshadriThe Framingham Heart Study, Framingham.
Amir H KashaniDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland.

Funding

FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
South Texas Alzheimer's Disease Research CenterP30AG066546 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Sudha Seshadri · 2021 to 2026
$24.0M
Multidimensional Assessment of Brain Health as A Marker of Dementia Risk and ResilienceR01AG066524 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KASHANI, AMIR H, RAMACHANDRAN, VASAN S · 2020 to 2024
$9.7M
Assessment of Retinal Capillary Density, Morphology and Function in Retinal Vascular Disease Using Novel OCT Angiography Based MetricsR01EY030564 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H · 2019 to 2024
$3.5M
NEI NIH HHS R01 EY030564NHLBI NIH HHS 75N92019D00031NIA NIH HHS P30 AG066546NIA NIH HHS R01 AG066524
6 · The paper itself

Abstract

BACKGROUND AND

objectiveThis study aimed to quantify the effects of four common artifacts of optical coherence tomography angiography (OCTA) on metrics of perfusion. PATIENTS AND

methodsData from the Framingham Heart Study were reviewed to select consecutive OCTA scans with and without representative image artifacts. Four artifact categories were defined (decentration, motion, shadowing, defocus) and graded using a severity scale of "Not Present," "Mild," or "Severe." Multivariate linear mixed-effects models were used to assess the impact of each artifact on vessel skeleton density (VSD), vessel area density (VAD), and flux.

resultsThe study included 141 OCTA scans from 20 participants. Severe shadowing or any severity of defocus significantly attenuated all OCTA parameters. Severe decentration significantly attenuated VAD and flux, but not VSD. Motion artifacts and mild decentration had no significant effects.

conclusionImage defocus and shadowing significantly affect all OCTA measures. VSD is the most robust measure against most artifacts.

Indexed as

ArtifactsFluorescein AngiographyRetinal VesselsTomography, Optical CoherenceAgedFemaleHumansMaleMiddle AgedRegional Blood Flow

Identifiers

PMID42274715
PMCPMC13289213

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.