Evidence map›Paper›PMID 42274675›Full record

ArticleNanomaterials (Basel, Switzerland)2026

Developing a New Approach Methodology Framework to Assess Biological Responses to Nanoplastics: Insights from Polystyrene and Biodegradable Particles.

Chiara Ritarossi, Simonetta Palleschi, Maria Condello, Barbara Rossi, Luca Pannone, Chiara Laura Battistelli, Cecilia Bossa, Giovanni Libralato, Simone Martinelli, Cristina Andreoli

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chiara RitarossiEnvironment and Health Department, Istituto Superiore di Sanità, 00161 Rome, Italy.
Simonetta PalleschiEnvironment and Health Department, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-2180-0168
Maria CondelloNational Center for Drug Research and Evaluation, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-2802-9142
Barbara RossiEnvironment and Health Department, Istituto Superiore di Sanità, 00161 Rome, Italy.
Luca PannoneDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0001-7027-8196
Chiara Laura BattistelliEnvironment and Health Department, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-2386-0727
Cecilia BossaEnvironment and Health Department, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-2084-2902
Giovanni LibralatoDepartment of Biology, University of Naples Federico II, Via Cinthia 26, 80126 Naples, Italy.ORCID 0000-0001-8507-900X
Simone MartinelliDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0002-5843-419X
Cristina AndreoliEnvironment and Health Department, Istituto Superiore di Sanità, 00161 Rome, Italy.ORCID 0000-0003-3724-0668

Funding

Ministry of Health CUP: I55I22000510001
6 · The paper itself

Abstract

The widespread presence of micro- and nanoplastics (MNPs) in the environment represents an emerging risk for human and environment health. New Approach Methodologies (NAMs) offer valuable tools to improve the mechanistic understanding of nanoscale processes and support hazard identification without animal testing. This study investigated the biological effects of exposure to 0-100 µg/mL 100 and 20 nm polystyrene (PS-NPs) and 100 nm polycaprolactone nanoplastics (PCL-NPs) using advanced in vitro intestinal models and the 3R-compliant in vivo

Indexed as

barrier integritybiodegradable plasticsC. elegansgenotoxicityin vitro intestinal barrier modelmicroplasticsNAMsnanoplasticsoxidative stresspolycaprolactone nanoplasticspolystyrene nanoplastics

Identifiers

PMID42274675
PMCPMC13258071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.