Evidence map›Paper›PMID 42274628›Full record

ArticleCells2026

Deciphering the Pleiotropic Role of

Pawel Kordowitzki, Renata Voltolini Velho, Sandra Bock, Jalid Sehouli, Sylvia Mechsner

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pawel KordowitzkiDepartment of Basic and Preclinical Sciences, Nicolaus Copernicus University, 87-100 Torun, Poland.ORCID 0000-0002-3344-5060
Renata Voltolini VelhoDepartment of Gynecology with Center for Oncological Surgery, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Sandra BockDepartment of Gynecology with Center for Oncological Surgery, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Jalid SehouliDepartment of Gynecology with Center for Oncological Surgery, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.
Sylvia MechsnerDepartment of Gynecology with Center for Oncological Surgery, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.

Funding

Federal Ministry of Research, Technology and Space 01EJ2402ANicolaus Copernicus University FemLife_OMICS
6 · The paper itself

Abstract

backgroundGiven the challenges in early detection and diagnosis, understanding the molecular underpinnings of endometrioid ovarian cancer (EOC) is crucial for improving patient outcomes. This multi-level study provides a new perspective on EOC, focusing on the expression of

methodsThis study evaluates patient cohorts with EOC through semi-quantitative immunohistochemical staining of BAF250a (protein encoded by

resultsHistological and immunohistochemical analysis of clinical samples revealed a significant reciprocal alteration in protein expression, characterized by a marked reduction in the tumor suppressor BAF250a (

conclusionsIn conclusion, our study offers a new perspective, emphasizing that EOC is a distinct clinical and molecular entity. We demonstrated the expression patterns of ARID1a/BAF250a and RIF1 in EOC, establishing their potential relevance in the context of tumor biology and malignant transformation.

Indexed as

Carcinoma, EndometrioidDNA-Binding ProteinsOvarian NeoplasmsTelomere-Binding ProteinsTranscription FactorsBRCA1 ProteinFemaleGene Expression Regulation, NeoplasticHumansMiddle AgedMutationARID1A protein, humanBRCA1 ProteinDNA-Binding ProteinsRif1 protein, humanTelomere-Binding ProteinsTranscription FactorsARID1aBRCA1endometrioid ovarian cancerendometriosisLAMB3RIF1

Identifiers

PMID42274628
PMCPMC13257199

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.