Evidence map›Paper›PMID 42274620›Full record

ArticleCells2026

SIRT7 Inhibits Adipose Tissue Browning Through Deacetylation of PPARγ2 at K382.

Avizit Das, Tatsuya Yoshizawa, Daisuke Yamada, Tomonori Tsuyama, Yoshifumi Sato, Tomoya Mizumoto, Takeshi Yoneshiro, Shingo Kajimura, Kazuya Yamagata

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Avizit DasDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.ORCID 0000-0002-1071-3042
Tatsuya YoshizawaDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.ORCID 0000-0002-5728-1996
Daisuke YamadaCell Biology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 606-0823, Japan.
Tomonori TsuyamaCenter for Metabolic Regulation of Healthy Aging, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.ORCID 0000-0002-3723-3938
Yoshifumi SatoDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.ORCID 0000-0003-0697-1476
Tomoya MizumotoDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.
Takeshi YoneshiroDivision of Molecular Physiology and Metabolism, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.ORCID 0000-0001-5298-5831
Shingo KajimuraBeth Israel Deaconess Medical Center, Harvard Medical School, and Howard Hughes Medical Institute, Boston, MA 02215, USA.ORCID 0000-0003-0672-5910
Kazuya YamagataDepartment of Medical Biochemistry, Faculty of Life Sciences, Kumamoto University, Kumamoto 860-8556, Japan.ORCID 0000-0001-7564-7579

Funding

Grants-in-aid for scientific research (B) 22H03129, 25K02701, 23H03311Naito Foundation NATakeda Science Foundation NA
6 · The paper itself

Abstract

Adipose tissue (AT) browning is an inducible cellular phenomenon that promotes lipid oxidation to increase energy expenditure, reducing adiposity. Various transcription regulators involved in the AT browning process have been reported, but their complex molecular mechanisms remain poorly understood. Here, we explore the effects of SIRT7, one of seven mammalian sirtuins, on AT browning and elucidate the underlying mechanisms. SIRT7 deficiency increased the expression of browning genes in beige adipocytes differentiated from subcutaneous white AT (scWAT) stromal vascular fraction (SVF) cells isolated from adipocyte-specific

Indexed as

Adipose Tissue, BrownPPAR gammaSirtuinsAcetylationAdipocytes, BeigeAnimalsCell DifferentiationDNA-Binding ProteinsHumansMaleMiceMice, Inbred C57BLMice, KnockoutTranscription FactorsDNA-Binding ProteinsPPAR gammaPrdm16 protein, mouseSIRT7 protein, humanSirt7 protein, mouseSirtuinsTranscription Factorsbeige adipocytesbrowningdeacetylationPPARγPRDM16SIRT7

Identifiers

PMID42274620
PMCPMC13256863

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.