Evidence map›Paper›PMID 42274603›Full record

ArticleCells2026

Distinct Serum and Tissue Markers Predict Fibrosis in Crohn's Disease.

Ahmed Abomhya, Ronaldo Panganiban, Syed Adeel Hassan, Brandon B Phinney, Steven McAninch, Gregory Yochum, Irina V Pinchuk, Terrence Barrett, Ellen J Beswick

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmed AbomhyaDivision of Digestive Diseases, Department of Internal Medicine, University of Kentucky, Lexington, KY 40506, USA.
Ronaldo PanganibanDivision of Gastroenterology and Hepatology, Department of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.ORCID 0000-0002-5626-3147
Syed Adeel HassanDivision of Digestive Diseases, Department of Internal Medicine, University of Kentucky, Lexington, KY 40506, USA.
Brandon B PhinneyDivision of Molecular Medicine, Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Steven McAninchDivision of Gastroenterology and Hepatology, Department of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Gregory YochumDepartment of Surgery, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Irina V PinchukDivision of Gastroenterology and Hepatology, Department of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA.
Terrence BarrettDivision of Digestive Diseases, Department of Internal Medicine, University of Kentucky, Lexington, KY 40506, USA.
Ellen J BeswickDivision of Digestive Diseases, Department of Internal Medicine, University of Kentucky, Lexington, KY 40506, USA.ORCID 0000-0003-4147-5777

Funding

United States Department of Defense W81XWH-22-1-0433United States Department of Defense W81XWH-22-1-0434
6 · The paper itself

Abstract

Fibrosis in Crohn's Disease (CD) occurs when there is continuous inflammation and repair mechanisms, which may lead to fibrotic strictures and ultimately intestinal surgical resection. There are limited non-invasive biomarkers for monitoring CD activity, particularly for detecting fibrosis. Thus, we set out to identify biomarkers that could be monitored for the detection and treatment of fibrosis. We used multiplex protein arrays to examine cytokines and pro-fibrotic factors in the serum of CD patients and analyzed their reliability to predict fibrosis. These markers were confirmed in tissues and the role of cytokines in upregulating fibrotic factors was examined. Collagen 1A1, Fibronectin, MMP9, and Timp-1 in patient serum were identified as strong predictors of fibrosis. IL-1β, MCP-1 and TNFα were identified as major regulators of fibrosis factors in human tissues. Overall, we identified four serum markers that are strong indicators of fibrosis and provided some novel insight into the impact of cytokines on fibrotic factors. Taken together, these findings may lead to earlier detection of fibrosis, and improved monitoring and treatment for CD patients.

Indexed as

BiomarkersCrohn DiseaseAdultCollagen Type ICytokinesFemaleFibronectinsFibrosisHumansMaleMatrix Metalloproteinase 9Tissue Inhibitor of Metalloproteinase-1BiomarkersCollagen Type ICytokinesFibronectinsMatrix Metalloproteinase 9Tissue Inhibitor of Metalloproteinase-1biomarkersCollagen 1A1Crohn’s DiseasefibronectinfibrosisMMP9Timp-1

Identifiers

PMID42274603
PMCPMC13256602

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.