Evidence map›Paper›PMID 42274570›Full record

ArticleCells2026

Detection of Vaccine-Derived Spike Protein Associated with Immune Cell Infiltration in the Heart and Liver: A Report of Two Cases.

Michael Mörz, Alberto Donzelli, Robert Llewellyn Clancy, Shigetoshi Sano, Masanori Fukushima, Panagis Polykretis

Abstract readCase Reports
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael MörzInstitute of Pathology "Georg Schmorl", Municipal Hospital Dresden-Friedrichstadt Site, 01067 Dresden, Germany.
Alberto DonzelliIndependent Medical Scientific Commission (CMSi), 20122 Milano, Italy.
Robert Llewellyn ClancySchool of Medicine and Public Health, University of Newcastle, Newcastle 2000, Australia.
Shigetoshi SanoDepartment of Dermatology, Kochi Medical School, Kochi University, Nankoku-shi 783-8505, Japan.
Masanori FukushimaLearning Health Society Institute, Nagoya 450-0003, Japan.ORCID 0000-0002-5456-3891
Panagis PolykretisIndependent Medical Scientific Commission (CMSi), 20122 Milano, Italy.ORCID 0000-0001-7911-1691

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rapid development and deployment of COVID-19 genetic vaccines have raised significant concerns regarding their safety and potential to trigger immune reactions against self-tissues. This paper provides a comprehensive histopathologically supported analysis of how the synthesis of the vaccine-derived spike protein can trigger such reactions beyond the injection site, characterized by robust immune cell recruitment. We examine these immune responses based on histopathological evidence that delineates a pattern consistent with self-directed immune activity, including vaccine-associated myocarditis. In this regard, we report two representative cases, marked by immune-cell infiltration, triggered by the synthesis of the vaccine-derived spike protein in the myocardium and in the liver, respectively. Additionally, we provide a detailed characterization of the process and the immune cells involved in these reactions, based on histopathological findings. Understanding these mechanisms is essential for accurately assessing the potential implications of these vaccination technologies on human health. By emphasizing the need for further research into the pharmacokinetics and off-target effects of COVID-19 genetic vaccines, this paper aims to deepen our understanding of their safety profiles and inform future vaccine development.

Indexed as

COVID-19COVID-19 VaccinesLiverMyocardiumSpike Glycoprotein, CoronavirusAgedAged, 80 and overHumansMaleMyocarditisSARS-CoV-2COVID-19 VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2adverse reactionsautoimmunityCOVID-19 genetic vaccinesimmune cell recruitmentinflammation

Identifiers

PMID42274570
PMCPMC13256085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.