Modeling Human Hypertrophic Scars with Induced Pluripotent Stem-Cell-Derived Scar Organoids Versus Skin Organoids.

Hyun Mi Kim, Eun Jung Oh, Suin Kwak, Se Ok Han, Ho Yun Chung

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hyun Mi KimBK21 FOUR KNU Convergence Educational Program of Biomedical Science for Creative Further Talents, Department of Medical Science, Kyungpook National University, Daegu 41944, Republic of Korea.ORCID 0000-0002-0577-4836

Eun Jung OhDepartment of Plastic and Reconstructive Surgery, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.

Suin KwakDepartment of Plastic and Reconstructive Surgery, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.ORCID 0000-0002-5939-2550

Se Ok HanDepartment of Plastic and Reconstructive Surgery, Cell and Matrix Research Institute, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.ORCID 0009-0005-4863-0508

Ho Yun ChungBK21 FOUR KNU Convergence Educational Program of Biomedical Science for Creative Further Talents, Department of Medical Science, Kyungpook National University, Daegu 41944, Republic of Korea.ORCID 0000-0001-7359-3044

Funding

National Research Foundation of Korea No. 2023R1A2C2004906National Research Foundation of Korea NRF-2022R1I1A3069687

6 · The paper itself

Abstract

Hypertrophic scars are characterized by excessive collagen deposition, fibrotic remodeling, and functional impairment. However, the ability of current models is limited in recapitulating human pathology. This study presents a novel approach using induced pluripotent stem cell-derived scar organoids to model hypertrophic scar characteristics in vitro. Following established protocols, human pluripotent stem cells were differentiated into skin organoids and induced fibrotic transformation by treatment with TGF-β1 (10 ng/mL) and hypoxia (5% O

Indexed as

Cicatrix, HypertrophicInduced Pluripotent Stem CellsModels, BiologicalOrganoidsSkinCell DifferentiationHair FollicleHumansdisease modelextracellular matrixhiPSChypertrophic scarsorganoidspluripotent stem cellscar organoidsskin

Identifiers

PMID42274563

DOI10.3390/cells15110969

PMCPMC13256951

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.