Evidence map›Paper›PMID 42274543›Full record

ArticleBiology2026

Multi-Omics Dissection of the Shared Genetic Architecture Between Sleep Traits and Epilepsy.

Tao Wang, Jun Li, Dinghao Chen, Yunbao Liu, Canteng Fang, Xinyue Wang, Zhenjue Song, Minyu Guo, Yubo Wang, Nenad Naumovski and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tao WangKey Laboratory of Laboratory Medicine, Ministry of Education, Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou 325035, China.
Jun LiZhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.ORCID 0000-0001-9668-343X
Dinghao ChenZhejiang Provincial Key Laboratory of Medical Genetics, Key Laboratory of Laboratory Medicine, Ministry of Education, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.
Yunbao LiuSchool of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China.
Canteng FangSchool of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China.
Xinyue WangSchool of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China.
Zhenjue SongSchool of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China.
Minyu GuoSchool of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China.
Yubo WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.ORCID 0000-0001-8248-8959
Nenad NaumovskiFood, Chemical and Biotechnology Cluster, Singapore Institute of Technology, Singapore 828608, Singapore.ORCID 0000-0002-2841-4497
Xing ZhengDepartment of Nutrition and Food Hygiene, School of Public Health, Wenzhou Medical University, Wenzhou 325035, China.ORCID 0000-0003-0896-2733

Funding

National Natural Science Foundation of China 32400603Research Foundation of Wenzhou Medical University 89225045Zhejiang Provincial Natural Science Foundation of China LQ24H110004
6 · The paper itself

Abstract

Epilepsy is a heritable neurological disorder that is frequently comorbid with sleeping difficulties, including short/long sleep duration and insomnia. Although epidemiological studies have consistently reported the comorbidity between sleep disturbances and epilepsy, the shared genetic architecture and molecular mechanisms underlying this relationship remain poorly characterized, hindering therapeutic development. In this study, we integrated large-scale genome-wide association study (GWAS) summary statistics of European ancestry to dissect the genetic and molecular links between sleep traits and epilepsy. Using LDSC and GWAS-pw, we identified modest but statistically significant (Bonferroni-corrected) global and local genetic correlations between sleep behaviors and epilepsy. Subsequent CPASSOC cross-trait meta-analysis and transcriptome-wide association studies (TWAS) pinpointed specific pleiotropic loci and shared candidate genes, including

Indexed as

causal relationshipepilepsygenetic architecturepleiotropy effectsleep behaviors

Identifiers

PMID42274543
PMCPMC13256046

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.