Evidence map›Paper›PMID 42274531›Full record

ArticleBiology2026

EZH2 Regulates the Pluripotency of Mouse Embryonic Stem Cells by Modulating

Fangfang Wu, Zhihui Liu, Yuan Gao, Jinshan Li, Xiao Chen, Xiyue Wang, Lanjun Liu, Fuliang Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fangfang WuSchool of Nursing and Health, Shanghai Zhongqiao Vocational and Technical University, Shanghai 200540, China.
Zhihui LiuCollege of Animal Science and Technology, Hebei Agricultural University, Baoding 071000, China.
Yuan GaoJiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210046, China.ORCID 0009-0002-5270-0503
Jinshan LiJiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210046, China.
Xiao ChenJiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210046, China.
Xiyue WangChildren's Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lanjun LiuChengdu Institute of Biological Products Co., Ltd., 379, 3rd Section, Jinhua Road, Jinjiang District, Chengdu 610023, China.
Fuliang DuJiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210046, China.ORCID 0000-0003-3576-7087

Funding

National Natural Science Foundation of China 32072732 and 32372877
6 · The paper itself

Abstract

Polycomb repressive complex 2 (PRC2) regulates the expression of pluripotency genes in embryonic stem cells (ESCs) and suppresses multiple genes associated with development, cell fate determination, and differentiation. Mouse embryonic stem cells (mESCs) derived from protein kinase C inhibition (PKCi) exhibit self-renewal and pluripotency comparable to those ESCs captured by the classical 2iL (CHIR99021, PD0325901, and leukemia inhibitory factor) system. However, the dynamic expression pattern of PRC2 in PKCi-mESCs and its role in regulating pluripotency remain unclear. This study demonstrated that the expression level of the enhancer of zeste 2 gene (

Indexed as

embryonic stem cellsepigeneticsEZH2Nanog

Identifiers

PMID42274531
PMCPMC13255847

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.