Evidence map›Paper›PMID 42274506›Full record

ArticleBiology2026

Integrated 16S rRNA Sequencing and Metabolomic Analyses Reveal Gut Microbiota Dysbiosis and Metabolic Perturbations in Neonatal Dairy Calves with Bovine Rotavirus-Induced Diarrhea.

Youli Yu, Yuxi Zhao, Wei He, Zhengqing Yu, Yuqiu Yang, Jiandong Wang

Abstract read
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Youli YuInstitute of Animal Science, Ningxia Academy of Agricultural and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China.
Yuxi ZhaoInstitute of Animal Science, Ningxia Academy of Agricultural and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China.ORCID 0000-0002-2080-3412
Wei HeNingxia Hui Autonomous Region Food Testing and Research Institute, No. 577, Fengyue Lane, Zhengyuan South Street, Jinfeng District, Yinchuan 750002, China.ORCID 0000-0003-1083-9427
Zhengqing YuCollege of Animal Science and Technology, Ningxia University, No. 539, Helanshan West Road, Xixia District, Yinchuan 750021, China.
Yuqiu YangCollege of Animal Science and Technology, Ningxia University, No. 539, Helanshan West Road, Xixia District, Yinchuan 750021, China.
Jiandong WangInstitute of Animal Science, Ningxia Academy of Agricultural and Forestry Sciences, No. 590, Huanghe East Road, Jinfeng District, Yinchuan 750002, China.ORCID 0000-0002-9207-5100

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bovine rotavirus (BRV) is a major pathogen causing diarrhea in neonatal dairy calves, yet its impact on the gut microbiome and host metabolism remains incompletely understood. This study integrated 16S rRNA gene sequencing and untargeted metabolomics to characterize the fecal microbial and metabolic profiles of BRV-infected diarrheic calves compared to healthy controls. Fecal samples were collected from 16 Holstein calves (<30 days old), equally divided into a BRV-infected group (confirmed by RT-qPCR) and a healthy control group. Alpha diversity analysis revealed a significant reduction in microbial richness (Chao1,

Indexed as

16S rRNA sequencingbovine rotavirusdiarrhea dairy calfgut microbiotalipid metabolismmetabolomicsmicrobial dysbiosismulti-omics integration

Identifiers

PMID42274506
PMCPMC13255632

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.