Evidence map›Paper›PMID 42274488›Full record

ArticleBiology2026

Characterization of Recombinant GMPR from

Latha Kannan, Jaden Jones, Meghana Hosahalli Shivananda Murthy, Giovanna Ghirlanda, Judith Klein-Seetharaman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Latha KannanSchool of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA.ORCID 0009-0007-1798-2046
Jaden JonesSchool of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA.
Meghana Hosahalli Shivananda MurthySchool of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA.ORCID 0000-0002-2952-9114
Giovanna GhirlandaSchool of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA.
Judith Klein-SeetharamanSchool of Molecular Sciences, Arizona State University, Tempe, AZ 85281, USA.ORCID 0000-0002-4892-6828

Funding

Arizona State University Startup FundsU.S. National Science Foundation OAC-1940169U.S. National Science Foundation RAPID 2031614
6 · The paper itself

Abstract

One potential strategy to mitigate the detrimental effects of heat stress on corals is upwelling, which brings deep, cold, nutrient-rich water to the reef surface, creating transient cooling. However, cold temperatures can also stress corals, and it is, therefore, important to understand the mechanisms of both cold and heat stress responses in corals. Similar to how mammals activate thermogenic and adaptive metabolic pathways, corals may also regulate energy and redox metabolism under fluctuating environmental conditions. Guanosine monophosphate reductase (GMPR), a conserved enzyme in purine metabolism, plays a critical role in maintaining intracellular adenine and guanine nucleotide balance. To study this enzyme in corals, we expressed

Indexed as

adaptationclimate changeenzyme activityprotein expression and purificationresilienceupwelling

Identifiers

PMID42274488
PMCPMC13256074

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.