Evidence map›Paper›PMID 42274471›Full record

ArticleBiology2026

Triptolide Reduces Cholesterol Synthesis and Alleviates Neuroinflammation by Inhibiting CD33 in Alzheimer's Disease Development and Progression.

Yi Yang, Yue Ma, Pu Wang, Pei-Pei Guan

Abstract read
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yi YangCollege of Life and Health Sciences, Northeastern University, Shenyang 110819, China.
Yue MaCollege of Life and Health Sciences, Northeastern University, Shenyang 110819, China.ORCID 0009-0007-9047-606X
Pu WangCollege of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
Pei-Pei GuanCollege of Life and Health Sciences, Northeastern University, Shenyang 110819, China.

Funding

Natural Science Foundation of Top Talent of SZTU GDRC202404Shenzhen Medical Research Fund D2402007Special projects in key areas of ordinary universities in Guangdong Province 2025ZDZX2061
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, which has recently been found to be closely associated with neuroinflammation. As an anti-inflammatory drug, triptolide (TP), a natural diterpenoid from

Indexed as

Alzheimer’s diseaseCD33cholesterolneuroinflammationtriptolide

Identifiers

PMID42274471
PMCPMC13255628

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.