Evidence map›Paper›PMID 42274247›Full record

ArticlemSphere2026

Mirror microbial life and the dual use dilemma.

Michael J Imperiale, Arturo Casadevall

Abstract read
In one paragraph

Article in mSphere, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael J ImperialeDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-1218-6458
Arturo CasadevallDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.ORCID 0000-0002-9402-9167

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Life as we know it on Earth contains sugars and amino acids that are, for the most part, in only one of two chiral forms. However, it has been proposed that molecules with the opposite chirality, called mirror molecules, could have beneficial uses. This possibility has led to discussions of producing replicating unicellular organisms with the opposite chirality, or mirror life. These concepts in mirror biology present potential dual use concerns. In this manuscript, we apply a framework we previously developed for considering the benefits and risks of gain-of-function experiments with infectious agents. We conclude that while mirror molecules are worth pursuing, the potential risks of mirror organisms currently far outweigh the benefits.

Indexed as

StereoisomerismAmino AcidsCarbohydratesGenetic EngineeringMicroorganisms, Genetically-ModifiedAmino AcidsCarbohydratesbiosecuritydual usemirror biology

Identifiers

PMID42274247
PMCPMC13317228

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.